Description:
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IdeZProtease(IgG-specific)isarecombinantantibodyspecificproteaseclonedfromStreptococcusequisubspecieszooepidemicusthatrecognizesallhuman,sheep,monkey,andrabbitIgGsubclasses,specificallycleavingatasinglerecognitionsitebelowthehingeregion,yieldingahomogenouspoolofF(ab′)2andFcfragments.IdeZProteasemoreeffectivelycleavesmurineIgG2athanIdeS.
ProductSource
ClonedfromStreptococcusequisubspecieszooepidemicusandexpressedinE.coli.?ReagentsSupplied
Thefollowingreagentsaresuppliedwiththisproduct:
| Storeat(°C) | Concentration |
GlycoBuffer2 | -20 | 10X |
Notes:
Storeat-20°Cforuptotwoyears.IdeZProteaseefficientlycleaveshuman,humanized,chimeric,sheep,rabbitandmonkeyIgGaswellasmouseIgG2aandIgG3.IdeZProteasewillalsocleaveFc-fusionproteins,suchasEnbrel.IdeZProteasedoesnotcleavemouseIgG1orIgG2b,rat,porcine,bovineorgoatIgG.Italsodoesnotcleavenon-IgGisotypesincludingIgA,IgM,IgDandIgE.