Immunogen | SKW3cells |
Clone | CBR-IC31 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Isotype | IgG1κ |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgeneisamemberoftheintercellularadhesionmolecule(ICAM)family.AllICAMproteinsaretypeItransmembraneglycoproteins,contain2-9immunoglobulin-likeC2-typedomains,andbindtotheleukocyteadhesionLFA-1protein.ThisproteinisconstitutivelyandabundantlyexpressedbyallleucocytesandmaybethemostimportantligandforLFA-1intheinitiationoftheimmuneresponse.Itfunctionsnotonlyasanadhesionmolecule,butalsoasapotentsignallingmolecule.[providedbyRefSeq]. |
GeneSymbol | - ICAM-3
- ICAM-R
- CDW50
- CD50
- CDw50
|
PurificationMethod | ProteinGPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:ICAMproteinsareligandsfortheleukocyteadhesionproteinLFA-1(integrinalpha-L/beta-2).ICAM3isalsoaligandforintegrinalpha-D/beta-2.
SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
PTM:Uponstimulationbyaphysiologicstimulibecomesrapidlyandtransientlyphosphorylatedonserineresidues.
N-glycosylated;glycansconsistofamixtureoftri-andtetra-antennarycomplex-typechainsandhigh-mannosechains.
SEQUENCESIMILARITIES:Belongstotheimmunoglobulinsuperfamily.ICAMfamily.
Contains5Ig-likeC2-type(immunoglobulin-like)domains. |
MolecularWeight | 59kDacalculated |