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Millipore/MABT26 | Anti-E-cadherin Antibody, clone DECMA-1/MABT26/100 µg
  • Millipore/MABT26 | Anti-E-cadherin Antibody, clone DECMA-1/MABT26/100 µg

Millipore/MABT26 | Anti-E-cadherin Antibody, clone DECMA-1/MABT26/100 µg

價格: ￥3948.00 市場價: 6580.00
貨號: MABT26
品牌: Millipore
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    • Description
      CatalogueNumberMABT26
      DescriptionAnti-E-cadherinAntibody,cloneDECMA-1
      AlternateNames
      • CAM120/80
      • CD324antigen
      • Cadherin1,E-cadherin(epithelial)
      • cadherin1,type1
      • cadherin1,type1,E-cadherin(epithelial)
      • calcium-dependentadhesionprotein,epithelial
      • cell-CAM120/80
      BackgroundInformationCadherinsareafamilyoftransmembraneglycoproteinsinvolvedinCa2+-dependentcelltocellinteractions.Themembersofthefamilyaredifferentiallyexpressedinvarioustissuesandfunctioninthemaintenanceoftissueintegrity,morphogenesis,andmigration.CadherinsaredividedintotypeIandtypeIIsubgroups.TypeIcadherinsincludeepithelialcadherin(E-cadherin),neuralcadherin(N-cadherin),placentalcadherin(P-cadherin)andretinalcadherin(R-cadherin).TypeIIincludekidneycadherin(K-cadherin)andosteoblastcadherin(OB-cadherin).OneofthebestcharacterizedcadherinsisE-cadherin(epithelialcadherinorcadherin-1).Itconsistsofcalcium-bindingextracellulardomainsresponsIBLeforinteractionswithotherE-cadherinmoleculesonneighboringcellsandinteractionwithintegrinalphaEbeta7.ThecytoplasmicdomainofE-cadherinislinkedtotheactinCytoskeletonthroughcytoplasmiccateninproteins,thusestablishingacomplexlocalizedtoadherensjunctions.Incarcinomas,E-cadherinisfrequentlydownregulated,consistentwithitsfunctionofaninvasionsuppressorinnormalepithelia.
      ProductInformation
      FormatPurified
      Control
      • A431celllysate
      PresentationPurifiedratmonoclonalIgG1κinbuffercontainingPBSwithoutpreservative.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationThisAnti-E-cadherinAntibody,cloneDECMA-1isvalidatedforuseinWB,IH,IC,IP,FC,FUNCforthedetectionofE-cadherin.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry
      • Immunocytochemistry
      • Immunoprecipitation
      • FlowCytometry
      • AffectsFunction
      ApplicationNotesImmunohistochemistryAnalysis:1:300dilutionofthisantibodyhasbeenshowntodetectE-cadherininmouseGItracttissue.

      Inhibition:Apreviouslotwasusedbyanindependentlaboratoryininhibionstudies,blockingE-cadherinassociatedcelladhesion.(Vestweber,1985)

      FlowCytometryAnalysis:Apreviouslotwasusedbyanindependentlaboratoryinflowcytometryapplications.(Tang,1994)
      BIOLOGicalInformation
      ImmunogenMouseembryonalcarcinomacelllinePCC4
      CloneDecma-1
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRat
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      • Mouse
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • Arc-1
      • CD324
      • CDHE
      • Cadherin-1
      • E-cadherin
      • ECAD
      • LCAM
      • UVO
      • Uvomorulin
      • uvomorulin
      PurificationMethodProteinG
      UniProtNumber
      UniProtSummaryFUNCTION:Cadherinsarecalcium-dependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.CDH1isinvolvedinmechanismsregulatingcell-celladhesions,mobilityandproliferationofepithelialcells.Hasapotentinvasivesuppressorrole.Itisaligandforintegrinalpha-E/beta-7(bysimilarity).

      E-Cad/CTF2promotesnon-amyloidogenicdegradationofAbetaprecursors.HasastronginhibitoryeffectonAPPC99andC83production(bysimilarity).

      SUBUNITSTRUCTURE:Homodimer;disulfide-linked.Interactsdirectly,viathecytoplasmicdomain,withCTNNB1orJUPtoformthePSEN1/cadherin/cateninadhesioncomplexwhichconnectstotheactinskeletonthroughtheactinbindingofalpha-catenin.InteractionwithPSEN1,cleavesCDH1resultinginthedisassociationofcadherin-basedadherensjunctions(CAJs).InteractswithAJAP1,CTNND1andDLGAP5(bysimilarity).

      SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:ColocalizeswithDLGAP5atsitesofcell-cellcontactinintestinalepithelialcells.AnchoredtoactinMICROFILamentsthroughassociationwithalpha-,beta-andgamma-catenin.Sequentialproteolysisinducedbyapoptosisorcalciuminflux,resultsintranslocationfromsitesofcell-cellcontacttothecytoplasm(bysimilarity).

      TISSUESPECIFICTY:Non-neuralepithelialtissues.

      DEVELOPMENTALSTAGE:Inthetestis,expressionishighestinfetalgonad,thendecreases5-foldinnewborn.Detectablein7-day-oldbutnotin21-day-oldoradult.

      SEQUENCESIMILARITIES:Contains5cadherindomains.
      MolecularWeight~106kDaobservedMW.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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