Immunogen | RecombinantproteincorrespondingtohumanNkx2.2. |
Clone | 1C11 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Isotype | IgG2aκ |
SpeciesReactivity | |
SpeciesReactivityNote | DemonstratedtoreactwithMouse. PredictedtoreactwithHumanbasedonimmunogendesign. |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgenecontainsahomeoboxdomainandmaybeinvolvedinthemorphogenesisofthecentralnervoussystem.Thisgeneisfoundonchromosome20nearNKX2-4,andthesetwogenesappeartobeduplicatedonchromosome14intheformofTITF1andNKX2-8.Theencodedproteinislikelytobeanucleartranscriptionfactor.[providedbyRefSeq,Jul2008]. |
GeneSymbol | |
PurificationMethod | ProteinGPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:Actsasatranscriptionalactivator.RequiredforthemaintenanceofNEUROD1expressioninthehoromone-producingendocrinecellsofthepancreas.Maybeinvolvedinspecifyingdiencephalicneuromericboundaries,andincontrollingtheexpressionofgenesthatplayaroleinaxonalguidance.AssociateswithchromatinattheNEUROD1promoterregion.BindstoasubsetofconsensuselementswithintheNEUROD1promoter(Bysimilarity).
SUBUNITSTRUCTURE:InteractswithOLIG2(Bysimilarity).
SUBCELLULARLOCATION:Nucleus(Bysimilarity).
DOMAIN:ThehomeodomainisessentialforinteractionwithOLIG2(Bysimilarity).
SEQUENCESIMILARITIES:BelongstotheNK-2homeoboxfamily.
Contains1homeoboxDNA-bindingdomain. |
MolecularWeight | ~37kDaobserved. Uncharacterizedbandsmayappearat~25kDaand~300kDainsomelysates. |