Immunogen | Asyntheticpeptide,correspondingtoaa408-439(AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA)fromC-terminusofhumanc-myc,coupledtoKLH. |
Epitope | a.a.410-419 |
Clone | 9E10.3 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | MAB8864recognizesanoncoproteinof64-67kDa,identifiedasc-myc.Itseptiopespansbetweenaa410-419(EQKLISEEDL)whichisaspecificportionofanalphahelicalregionofhumanc-mycprotein.MAB8864showsnocross-reactionwithv-myc.c-mycisinvolvedinthecontrolofcellproliferationanddifferentiationandisamplifiedand/oroverexpressedinavarietyoftumors. |
Isotype | IgG1κ |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgeneisamultifunctional,nuclearphosphoproteinthatplaysaroleincellcycleprogression,apoptosisandcellulartransformation.Itfunctionsasatranscriptionfactorthatregulatestranscriptionofspecifictargetgenes.Mutations,overexpression,rearrangementandtranslocationofthisgenehavebeenassociatedwithavarietyofhematopoietictumors,leukemiasandlymphomas,includingBurkittlymphoma.Thereisevidencetoshowthatalternativetranslationinitiationsfromanupstream,in-framenon-AUG(CUG)andadownstreamAUGstartsiteresultintheproductionoftwoisoformswithdistinctN-termini.Thesynthesisofnon-AUGinitiatedproteinissuppressedinBurkitt"slymphomas,suggestingitsimportanceinthenormalfunctionofthisgene. |
GeneSymbol | |
Non-ReactiveSpecies | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P01106#Participatesintheregulationofgenetranscription.BindsDNAbothinanon-specificmannerandalsospecificallytorecognizesthecoresequence5"-CAC[GA]TG-3".Seemstoactivatethetranscriptionofgrowth-relatedgenes. SIZE:439aminoacids;48804Da SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasaheterodimerwithMAX.InteractswithTAF1CandSPAG9.InteractswithPARP10.InteractswithJARID1AandJARID1B. SUBCELLULARLOCATION:Nucleus. PTM:PhosphorylatedbyPRKDC. DISEASE:SwissProt:P01106#OverexpressionofMYCisimplicatedintheetiologyofavarietyofhematopoietictumors.&AchromosomalaberrationinvolvingMYCmaybeacauseofaformofB-cellchroniclymphocyticleukemia.Translocationt(8;12)(q24;q22)withBTG1. SIMILARITY:SwissProt:P01106##Contains1basichelix-loop-helix(bHLH)domain. |