Immunogen | RecombinantproteinfromtheC-terminusofhumanCHT. |
Clone | 62-2E8 |
Host | Mouse |
Specificity | Hemicholinium-3-sensitivecholinetransporter(CHT). |
Isotype | IgG1 |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Cholineisadirectprecursorofacetylcholine(ACh),aneurotransmitterofthecentralandperipheralnervoussystemthatregulatesavarietyofautonomic,cognitive,andmotorfunctions.SLC5A7isaNa(+)-andCl(-)-dependenthigh-affinitytransporterthatmediatestheuptakeofcholineforacetylcholinesynthesisincholinergicneurons(Apparsundarametal.,2000[PubMed11027560]).[suppliedbyOMIM] |
GeneSymbol | - SLC5A7
- MGC126299
- MGC126300
- CHT1
- hCHT
- CHT
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q9GZV3#Importscholinefromtheextracellularspacetotheneuronwithhighaffinity.Cholineuptakeistherate-limitingstepinacetylcholinesynthesis.Sodiumion-andchlorideion-dependent. SIZE:580aminoacids;63204Da SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Expressedinputamen,spinalcordandmedulla.Specificforcholinergicneurons. PTM:Phosphorylated(Bysimilarity). SIMILARITY:SwissProt:Q9GZV3##Belongstothesodium:solutesymporter(SSF)(TC2.A.21)family. MISCELLANEOUS:Specificallyinhibitedbynanomolarconcentrationsofhemicholinium3. |