Immunogen | Humanpheochromocytoma |
Clone | LK2H10 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | Chromogranin,anacidicproteinhavingamolecularweightofabout68kDaABIdesinthepolypeptide-hormone-containingsecretorygranulesofhumanendocrinetissues.Anti-chromograninAcanbeusedtostainmostnormalandneoplasticendocrinetissuescontainingsecretorygranules(exceptionsincludecellsfromthehypothalamusandposteriorpituitary,whichareknowntocontainsecretorygranules).Theamountofstainingisusuallyproportionaltothenumberofsecretorygranulespresent(1). |
Isotype | IgG1κ |
SpeciesReactivity | |
SpeciesReactivityNote | Human,mouse,rat,monkey,andporcine.Doesnotrecognizesheep,rabbitorguineapig. |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthechromogranin/secretograninfamilyofneuroendocrinesecretoryproteins.Itisfoundinsecretoryvesiclesofneuronsandendocrinecells.Thisgeneproductisaprecursortothreebiologicallyactivepeptides;vasostatin,pancreastatin,andparastatin.Thesepeptidesactasautocrineorparacrinenegativemodulatorsoftheneuroendocrinesystem.Otherpeptides,includingchromostatin,beta-granin,WE-14andGE-25,arealsoderivedfromthefull-lengthprotein.However,biologicalactivitiesforthesemoleculeshavenotbeenshown. |
GeneSymbol | |
PurificationMethod | AmmoniumSulfatePrecipitation |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P10645#Pancreastatinstronglyinhibitsglucoseinducedinsulinreleasefromthepancreas. SIZE:457aminoacids;50730Da SUBCELLULARLOCATION:Secreted.Note=Neuroendocrineandendocrinesecretorygranules. PTM:Sulfatedontyrosineresiduesand/orcontainssulfatedglycans. SIMILARITY:SwissProt:P10645##Belongstothechromogranin/secretograninproteinfamily. MISCELLANEOUS:Bindscalciumwithalow-affinity |
MolecularWeight | 50kDa |