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Millipore/MAB386 | Anti-Myelin Basic Protein Antibody, a.a. 82-87/MAB386/1 mL
  • Millipore/MAB386 | Anti-Myelin Basic Protein Antibody, a.a. 82-87/MAB386/1 mL

Millipore/MAB386 | Anti-Myelin Basic Protein Antibody, a.a. 82-87/MAB386/1 mL

價(jià)格: ￥3696.00 市場(chǎng)價(jià): 6160.00
貨號(hào): MAB386
品牌: Millipore
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    • Description
      CatalogueNumberMAB386
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-MyelinBasicProteinAntibody,a.a.82-87
      AlternateNames
      • MBP
      BackgroundInformationThetwomajorcomponentsofCNSmyelinareMyelinBasicProtein(MBP)andproteolipidprotein(PLP),occuringinroughlyequimolarproportions.Therearemanyneurologicaldisordersassociatedwithdeficienciesofmyelinassemblyandstructure.ForexampleMultipleSclerosisisahumandiseaseduetomultiplefactorsbutgenerallycharacterizedbythedegradationofthemyelinsheath.MBPususallyreferstothe18.5kDaisoform,whichisoneofthemostabundantproteinsofthemyelinsheathofadulthumanandbovineCNS.Genetically,MBPistheproductofdifferentialsplicingofasinglemRNAtranscript.Inhumansthereare4isoforms,21.5,20.2,18.5,and17.2kDa.Thus,MBParepresentinmultipleisoforms,partofalargefamilyofdevelopmentallyexpressed,translocatable,andhighlypost-translationallymodifedproteinswithmultiplebindingpartners.Structurally,MBPdisplaysapredominatelyunorganizedformwithgreaterthan75%inrandomcoil.Othernon-CNSrelatedfunctionsofmyelinincludeinsulininductionandglucagonreleasefrompancreaticislets.
      ProductInformation
      FormatAscites
      Control
      • Braintissue
      PresentationLiquidcontaining0.09%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      Applications
      ApplicationAnti-MyelinBasicProteinAntibody,a.a.82-87isanantibodyagainstMyelinBasicProteinforuseinELISA,IC,IH,RIA&WB.
      KeyApplications
      • ELISA
      • Immunocytochemistry
      • Immunohistochemistry
      • RADIoimmunoassay
      • WesternBlotting
      ApplicationNotesImmunohistochemistry:
      Apreviouslotofthisantibodywasusedonfrozensections.

      ELISA/RIA:
      1:1000dilutionofapreviouslotofthisantibodywasusedinELISA/RIA.

      WesternBlotting:
      Identifiesan18-20kDabandinwesterns.

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenBovinemyelinbasicprotein
      Epitopea.a.82-87
      Clone12
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRat
      SpecificityReactswithMBPfromallspeciestested.Itreactsweaklywithpeptidesendinginthephe91wherethe91-92phe-phebondisbroken.Syntheticpeptide82-99reactsverywellasdoesintactMBP.MappedtotheregionDENPVV.
      IsotypeIgG2a
      SpeciesReactivity
      • Bovine
      • Chicken
      • GuineaPig
      • Human
      • Mouse
      • Rat
      • Sheep
      • Rabbit
      SpeciesReactivityNoteReactswithMBPfromallspeciestestedincludinghuman,bovine,sheep,rabbit,mouse,rat,guineapigandchicken.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbytheclassicMBPgeneisamajorconstituentofthemyelinsheathofoligodendrocytesandSchwanncellsinthenervoussystem.However,MBP-relatedtranscriptsarealsopresentinthebonemarrowandtheimmunesystem.ThesemRNAsarisefromthelongMBPgene(otherwisecalled"Golli-MBP")thatcontains3additionalexonslocatedupstreamoftheclassicMBPexons.AlternativesplicingfromtheGolliandtheMBPtranscriptionstartsitesgivesriseto2setsofMBP-relatedtranscriptsandgeneproducts.TheGollimRNAscontain3exonsuniquetoGolli-MBP,splicedin-frameto1ormoreMBPexons.TheyencodehybridproteinsthathaveN-terminalGolliaasequencelinkedtoMBPaasequence.ThesecondfamilyoftranscriptscontainonlyMBPexonsandproducethewellcharacterizedmyelinbasicproteins.ThiscomplexgenestructureisconservedamongspeciessuggestingthattheMBPtranscriptionunitisanintegralpartoftheGollitranscriptionunitandthatthisarrangementisimportantforthefunctionand/orregulationofthesegenes
      GeneSymbol
      • MBP
      • MGC99675
      • Golli-mbp
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P02686#TheclassicgroupofMBPisoforms(isoform4-isoform14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.TheyhavearoleinbothitsformationandstABIlization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.Thenon-classicgroupofMBPisoforms(isoform1-isoform3/Golli-MBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinT-cellsandneuralcells.Differentialsplicingeventscombinedtooptionalpost-translationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.InducesT-cellproliferation.
      SIZE:304aminoacids;33117Da
      SUBUNIT:Homodimer;isoform3existsasahomodimer.
      SUBCELLULARLOCATION:Myelinmembrane;Peripheralmembraneprotein;Cytoplasmicside.Note=Cytoplasmicsideofmyelin.
      TISSUESPECIFICITY:MBPisoformsarefoundinboththecentralandtheperipheralnervoussystem,whereasGolli-MBPisoformsareexpressedinfetalthymus,spleenandspinalcord,aswellasincelllinesderivedfromtheimmunesystem.
      DEVELOPMENTALSTAGE:Expressionturnsonabruptlyinfetusof14to16weeks.Evensmallerisoformsseemtobeproducedduringembryogenesis,someofthesepersistingintheadult.ExpressionofisoformMBP2ismoreevidentat16weeksanditsrelativeproportiondeclinedthereafter.
      PTM:SeveralchargeisomersofMBP;C1(themostcationic,leastmodified,andmostabundantform),C2,C3,C4,C5,C6,C7,C8-AandC8-B(theleastcationicform);areproducedasaresultofoptionalPTM,suchasphosphorylation,deamidationofglutamineorasparagine,argininecitrullinationandmethylation.C8-AandC8-BcontaineachtwomassisoformstermedC8-A(H),C8-A(L),C8-B(H)andC8-B(L),(H)standingforhigherand(L)forlowermolecularweight.C3,C4andC5arephosphorylated.Theratioofmethylatedarginineresiduesdecreasesinaging,makingtheproteinmorecationic.&TheN-terminalalanineisacetylated(isoform3,isoform4,isoform5andisoform6).&Arg-241wasfoundtobe6%monomethylatedand60%symmetricallydimethylated.
      DISEASE:SwissProt:P02686#Thereductioninthesurfacechargeofcitrullinatedand/ormethylatedMBPcouldresultinaweakenedattachmenttothemyelinmembrane.Thismechanismcouldbeoperativeindemyelinatingdiseasessuchaschronicalmultiplesclerosis(MS),andfulminatingMS(Marburgdisease).
      SIMILARITY:SwissProt:P02686##Belongstothemyelinbasicproteinfamily.
      MolecularWeight18-20kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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