Immunogen | L2epitopecarryingglycoproteinextractof1-2dayoldchickenbrain. |
Clone | 513 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | DetectsMyelinAssociatedGlycoprotein(MAG)inimmunohistochemistryonfrozensections,immunocytochemistryandWesternblot(undernon-reducingconditions).MAB1567isusefulformyelinogenesisandmultiplesclerosisstudies. |
Isotype | IgG1 |
SpeciesReactivity | - Bovine
- Chicken
- Human
- Mouse
- Rat
- Frog
|
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | TheproteinencodedbythisgeneisatypeImembraneproteinandmemberoftheimmunoglobulinsuperfamily.Itisthoughttobeinvolvedintheprocessofmyelination.Itisalectinthatbindstosialylatedglycoconjugatesandmediatescertainmyelin-neuroncell-cellinteractions.Twoalternativelysplicedtranscriptsencodingdifferentisoformshavebeendescribedforthisgene. |
GeneSymbol | - MAG
- SIGLEC4A
- SIGLEC-4A
- Siglec-4a
- S-MAG
- GMA
|
PurificationMethod | ProteinAPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P20916#Adhesionmoleculeinpostnatalneuraldevelopmentthatmediatessialic-aciddependentcell-cellinteractionsbetweenneuronalandmyelinatingcells.Preferentiallybindstoalpha2,3-linkedsialicacid(Bysimilarity). SIZE:626aminoacids;69069Da SUBUNIT:BindstoRTN4R(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. SIMILARITY:SwissProt:P20916##Belongstotheimmunoglobulinsuperfamily.SIGLEC(sialicacidbindingIg-likelectin)family.&Contains4Ig-likeC2-type(immunoglobulin-like)domains.&Contains1Ig-likeV-type(immunoglobulin-like)domain. |
MolecularWeight | 100kDa |