Immunogen | Nestinpurifiedfromembryonicratspinalcord. |
Clone | rat-401 |
Host | Mouse |
Specificity | RodentNestinproteinconfirmedwithratandmouse.Rat-401isnotreactivewithhumannestinprotein. |
Isotype | IgG1 |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | NestinisanintermediatefilamentproteinthatwasfirstidentifiedwithamonoclonalantibodybyHockfieldandMcKay(1985)[PubMed4078630].Itisexpressedpredominantlyinstemcellsofthecentralnervoussystemintheneuraltube.Uponterminalneuraldifferentiation,nestinisdownregulatedandreplacedbyneurofilaments.[suppliedbyOMIM] |
GeneSymbol | - NES
- ORFNames=Nbla00170
- FLJ21841
- Nestin.
- Nbla00170
|
Non-ReactiveSpecies | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P48681#MayplayaroleinthetraffickinganddistributionofIFproteinsandpotentiallyothercellularfactorstodaughtercellsduringProgenitorcelldivision(Bysimilarity). SIZE:1621aminoacids;177439Da SUBUNIT:InteractswithFHOD3(Bysimilarity). TISSUESPECIFICITY:CNSstemcells. DEVELOPMENTALSTAGE:Uponterminalneuraldifferentiation,nestinisdown-regulatedandreplacedbyneurofilaments. SIMILARITY:SwissProt:P48681##Belongstotheintermediatefilamentfamily. |
StemCellType | - NeuralStemCells
- EpithelialCells
|