Immunogen | Rheumatoidsynovialcellsandfibronectinadherentmonocytes |
Clone | 15.2 |
Host | Mouse |
Specificity | ThisantibodyrecognizesICAM-1,a90kDaintegralmembraneglycoproteinwithsevenpotentialN-linkedglycosylationsites.ICAM-1istheprincipalligandofLFA-1.ICAM-1isalymphokineinducablemoleculeandmaybeusedinstudiesofLFA-1mediatedadhesion.Theantigenisexpressedonendothelialcellsandmanyothertypesofcellsonactivationincludinglymphocytesandfibroblasts. FUSIONPARTNER:SP2/0myelomacellline |
Isotype | IgG1 |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ICAM1(CD54)istypicallyexpressedonendothelialcellsandcellsoftheimmunesystem.ICAM1bindstointegrinsoftypeCD11a/CD18,orCD11b/CD18.ICAM1isalsoexploitedbyRhinovirusasareceptor. |
GeneSymbol | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P05362#ICAMproteinsareligandsfortheleukocyteadhesionproteinLFA-1(integrinalpha-L/beta-2).Incaseofrhinovirusinfectionactsasacellularreceptorforthevirus.Alsoactsasreceptorforsomecoxsackieviruses. SIZE:532aminoacids;57825Da SUBUNIT:Interactswithhumanherpesvirus8MIR2protein(Probable). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. PTM:Monoubiquitinated,whichispromotedbyMARCH9andleadstoendocytosis. SIMILARITY:SwissProt:P05362##Belongstotheimmunoglobulinsuperfamily.ICAMfamily.&Contains5Ig-likeC2-type(immunoglobulin-like)domains. |