UniProtSummary | FUNCTION:Mayplayaroleasalocalizedscaffoldfortheassemblyofamultiproteinsignalingcomplexandasmediatorofthetraffickingofitsbindingpartnersatspecificsubcellularlocationinneurons.
SUBUNITSTRUCTURE:InteractswithEFNB1,EPHA7,EPHB2,EFNB3,KIF5A,KIF5C,KIF5BandtheC-terminaltailofPRLHR.FormsaternarycomplexwithGRIA2andCSPG4(Bysimilarity).CanformhomomultimersorheteromultimerswithGRIP2.InteractswithGRIA2,GRIA3,GRIPAP1/GRASP1,PPFIA1,PPFIA4,FRAS1,PLCD4,PTPRFandliprins-alpha.InteractswithSLC30A9(Bysimilarity).
SUBCELLULARLOCATION:Cytoplasm.Endomembranesystem;Peripheralmembraneprotein.Celljunction?synapse?postsynapticcellmembrane.Celljunction?synapse?postsynapticcellmembrane?postsynapticdensity.Endoplasmicreticulummembrane;Peripheralmembraneprotein(Potential).Note:Membrane-associatedwithvesicles,peri-Golgicomplexesandendoplasmicreticulum.Enrichedinpost-synapticplasmamembraneandpost-synapticdensities.
TISSUESPECIFICTY:Expressedinbrain,testisandretina.Inbrainhighlyexpressedintheolfactorybulb,cortexandhyppocampusandlowerlevelinthalamus,cerebellumandspinalcord.Inbrainitisfoundintheperikaryon,dendrites,dendriticshafts,dendriticspinesand,excitatoryandinhibitorysynapsesofneurons.Inretina,itismostabundantintheplexiformlayersthaninperikarya.
DEVELOPMENTALSTAGE:DetectedinearlyembryonicstageasearlyasE15,graduallyincreasedthroughoutearlydevelopment,peakedatapproximatelybetweenpostnataldaysP6andP8,thenslightlydecreasedandremainedrelativelystableintheadult.
DOMAIN:PDZ6mediatesinteractionwiththePDZrecognitionmotifofEFNB1andEPHB2andwiththeC-terminusofPPFIA1andPPFIA4.PDZ4andPDZ5mediateinteractionwithPRLHR(Bysimilarity).PDZ4andPDZ5mediateinteractionwiththeC-terminusofGRIA2andGRIA3.PDZ4,PDZ5andPDZ6mediatehomomultimers.PDZ7mediatesinteractionwithPDZdomainofGRASP1.PDZ7domainbindsCSPG4.PDZ6mediatesinteractionwiththeC-terminusofliprins-alpha.PDZ1,PDZ2andPDZ3mediateinteractionwiththePDZ-bindingmotifofFRAS1.
SEQUENCESIMILARITIES:Contains7PDZ(DHR)domains. |