BackgroundInformation | Mammalsexpresssevendistinct14-3-3isoforms(gamma,epsilon,beta,zeta,sigma,theta,tau)thatformmultiplehomo-andhetero-dimmers,thusrendering14-3-3asakeymultifunctionalregulatorymolecule.14-3-3isomershavebeenimplicatedinseveralneurologicaldisorders:forexampleisoformsgamma,epsilonandbetaareexpressedinthecerebrospinalfluidofCreutzfeldt-Jakobpatients,butnotpatientssufferingfromotherneurologicalconditionssuchasAlzheimer"s.
The14-3-3phosphoSerine185antibodyisoneofapanelofantibodiesthatweregeneratedagainst14-3-3isoformsandhavedemonstratedtheirpotentialforuseasanELISA-baseddiagnostictool.TheseantibodieswillallowtheresearchtoinvestigatetheroleofthisproteininkeycellularprocessesandneurologicaldisorderssuchasCreutzfeldt-Jakob,Alzheimer"sandParkinson"sDisease. |