Immunogen | SyntheticpeptidefromtheN-terminalCUBdomainofhumanneuropilin-1. |
Host | Rabbit |
Specificity | Neuropilin-1.Theimmunogensequencehaslowhomologywithneuropilin-2. |
SpeciesReactivity | |
SpeciesReactivityNote | Itisexpectedthattheantibodywillalsoreactwithratandmouse. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | NRP1isamembrane-boundcoreceptortoatyrosinekinasereceptorforbothvascularendothelialgrowthfactor(VEGF;MIM192240)andsemaphorin(seeSEMA3A;MIM603961)familymembers.NRP1playsversatilerolesinangiogenesis,axonguidance,cellsurvival,migration,andinvasion.[suppliedbyOMIM] |
GeneSymbol | - NRP1
- neuropilin-1
- DKFZp781F1414
- VEGF165R
- NRP
- DKFZp686A03134
- CD304
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:O14786#Thesolubleisoform2bindsVEGF-165andappearstoinhibititsbindingtocells.ItmayalsoinduceapoptosisbysequesteringVEGF-165.Maybindaswellvariousmembersofthesemaphorinfamily.Itsexpressionhasanaverseeffectonbloodvesselnumberandintegrity. SIZE:923aminoacids;103120Da SUBUNIT:HeterodimerwithNRP2(Probable).BindsPLXNB1. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform2:Secreted. TISSUESPECIFICITY:Theexpressionofisoforms1and2doesnotseemtooverlap.Isoform1isexpressedbythebloodvesselsofdifferenttissues.Inthedevelopingembryoitisfoundpredominantlyinthenervoussystem.Inadulttissues,itishighlyexpressedinheartandplacenta;moderatelyinlung,liver,skeletalmuscle,kidneyandpancreas;andlowinadultbrain.Isoform2isfoundinliverhepatocytes,kidneydistalandproximaltubules. SIMILARITY:SwissProt:O14786##Belongstotheneuropilinfamily.&Contains2CUBdomains.&Contains2F5/8typeCdomains.&Contains1MAMdomain. |