Immunogen | Syntheticpeptidefromaminoacids458-472ofhumanStaufen1. |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | ReactswithStaufen1. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Staufenisamemberofthefamilyofdouble-strandedRNA(dsRNA)-bindingproteinsinvolvedinthetransportand/orlocalizationofmRNAstodifferentsubcellularcompartmentsand/ororganelles.TheseproteinsarecharacterizedbythepresenceofmultipledsRNA-bindingdomainswhicharerequiredtobindRNAshavingdouble-strandedsecondarystructures.ThehumanhomologueofstaufenencodedbySTAU,inadditioncontainsamicrotubule-bindingdomainsimilartothatofmicrotubule-associatedprotein1B,andbindstubulin.TheSTAUgeneproducthasbeenshowntobepresentinthecytoplasminassociationwiththeroughendoplasmicreticulum(RER),implicatingthisproteininthetransportofmRNAviathemicrotubulenetworktotheRER,thesiteoftranslation.FivetranscriptvariantsresultingfromalternativesplicingofSTAUgeneandencodingthreeisoformshavebeendescribed.Threeofthesevariantsencodethesameisoform,however,differintheir5"UTR. |
GeneSymbol | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:O95793#Bindsdouble-strandedRNA(regardlessofthesequence)andtubulin.MayplayaroleinspecificpositioningofmRNAsatgivensitesinthecellbycross-linkingcytoskeletalandRNAcomponents,andinstimulatingtheirtranslationatthesite. SIZE:577aminoacids;63182Da SUBUNIT:Bindstubulin.Bindswithlowaffinitysingle-strandedRNAorDNAhomopolymers.InteractswithCASC3inanRNA-dependentmanner(Bysimilarity).InteractswiththeinfluenzavirusnonstructuralproteinNS1. SUBCELLULARLOCATION:Roughendoplasmicreticulum.Note=Localizesexclusivelywiththeroughreticulumendoplasmic(RER). TISSUESPECIFICITY:Widelyexpressed.Expressedinbrain,pancreas,heart,skeletalmuscles,liver,lung,kidneyandplacenta. DOMAIN:SwissProt:O95793OneoftheDRDBcouldbeinvolvedinRERbinding.&TheC-terminalcontainsthetubulinbindingdomain(TBD)(Bysimilarity). SIMILARITY:Contains3DRBM(double-strandedRNA-binding)domains. |