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Millipore/AB4251 | Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular/AB4251/50 µg
  • Millipore/AB4251 | Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular/AB4251/50 µg

Millipore/AB4251 | Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular/AB4251/50 µg

價格: ￥4308.00 市場價: 7180.00
貨號: AB4251
品牌: Millipore
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    • Description
      CatalogueNumberAB4251
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-CXCChemokineReceptor4Antibody,NT,extracellular
      AlternateNames
      • CXCR4
      BackgroundInformationCXCR4isachemokinereceptorinvolvedinorganvascularization,neuronalcellmigration,andpatterningofthecentralnervoussystemduringdevelopment.Itbindsstromalcell-derivedfactor1(SDF1)andmediatesmigrationofrestingleukocytesandisuniqueinhominghematopoieticProgenitorstobonemarrow.ThesepropertiessuggestthatCXCR4isinvolvedintumorcellmigrationandlocaltumorinvasion.ItisalsoanHIV-1fusionco-factorthatallowsHIV-1invasionindiversehumancelltypes.CXCR4hastwoisoformsthatareproducedbyalternativesplicingandhasbeenreportedtobeexpressedincellsoftheimmuneandcentralnervoussystems.Itishighlyexpressedinbrainandheart,andinwhitebloodcells,vascularendothelialcells,andumbilicalcordendothelialcells.Inbraintumors,CXCR4isexpressedinregionsofangiogenesisanddegenerative,necrotic,andmicrocysticchanges(Rempeletal.,2000).ESTshavebeenisolatedfromawidevarietyoftissuelibraries,particularlyuterus,kidney,lung,tonsil,andbrain.
      ProductInformation
      FormatAffinityPurified
      PresentationPeptide-affinitypurifiedimmunoglobulin.Liquidinphosphatebufferedsaline,pH7.7,containing0.01%sodiumazide
      StorageandShippingInformation
      StorageConditionsMaintainat-70°Cinundilutedaliquotsforupto12monthsfromdateofreceipt.Maybestoredat2-8°Cforshorttermuse.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationThisAnti-CXCChemokineReceptor4Antibody,N-terminal,extracellularisvalidatedforuseinIH(P)forthedetectionofCXCChemokineReceptor4.
      KeyApplications
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunohistochemistry(formalin-fixedparaffin-embeddedtissues)

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoasequencewithintheN-terminalextracellulardomainofhumanCXCR4.Theimmunogenhas93%homologywithmouseandrat.
      EpitopeN-terminal,extracellular
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizeshumanCXCR4.ThespecificityofthisantibodyhasbeenconfirmedbyIHCstainingofcardiacmyocytesinhumanheart.
      SpeciesReactivity
      • Human
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesaCXCchemokinereceptorspecificforstromalcell-derivedfactor-1.Theproteinhas7transmembraneregionsandislocatedonthecellsurface.ItactswiththeCD4proteintosupportHIVentryintocellsandisalsohighlyexpressedinbreastcancercells.MutationsinthisgenehavebeenassociatedwithWHIM(warts,hypogammaglobulinemia,infections,andmyelokathexis)syndrome.Alternatetranscriptionalsplicevariants,encodingdifferentisoforms,havebeencharacterized.
      GeneSymbol
      • CXCR4
      • WHIM
      • NPY3R
      • NPYY3R
      • FB22
      • LAP3
      • Fusin
      • CXCR-4
      • LCR1
      • NPYR
      • HM89
      • fusin
      • HSY3RR
      • CXC-R4
      • NPYY3
      • NPYRL
      • CD184
      • D2S201E
      • LESTR
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P61073#ReceptorfortheC-X-CchemokineCXCL12/SDF-1.Transducesasignalbyincreasingtheintracellularcalciumionslevel.Involvedinhaematopoiesisandincardiacventricularseptumformation.Playsalsoanessentialroleinvascularizationofthegastrointestinaltract,probablybyregulatingvascularbranchingand/orremodelingprocessesinendothelialcells.Couldbeinvolvedincerebellardevelopment.IntheCNS,couldmediatehippocampal-neuronsurvival.Actsasacoreceptor(CD4beingtheprimaryreceptor)forHIV-1X4isolatesandasaprimaryreceptorforsomeHIV-2isolates.PromotesEnv-mediatedfusionofthevirus.
      SIZE:352aminoacids;39746Da
      SUBUNIT:InteractswithHIV-1surfaceproteingp120andTat.
      SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein.
      TISSUESPECIFICITY:Expressedinnumeroustissues,suchasperipheralbloodleukocytes,spleen,thymus,spinalcord,heart,placenta,lung,liver,skeletalmuscle,kidney,pancreas,cerebellum,cerebralcortexandmedulla(inmicrogliaaswellasinastrocytes),brainmicrovascular,coronaryarteryandumbilicalcordendothelialcells.Isoform1ispredominantinalltissuestested.
      DOMAIN:SwissProt:P61073Theamino-terminusiscriticalforligandbinding.ResiduesinallfourextracellularregionscontributetoHIV-1coreceptoractivity.
      PTM:Sulfated.
      DISEASE:SwissProt:P61073#DefectsinCXCR4areacauseofWHIMsyndrome[MIM:193670];alsocalledwarts,hypogammaglobulinemia,infections,andmyelokathexis.WHIMsyndromeisanimmunodeficiencydiseasecharacterizedbyneutropenia,hypogammaglobulinemiaandextensivehumanpapillomavirus(HPV)infection.Despitetheperipheralneutropenia,bonemarrowaspiratesfromaffectedindividualscontainabundantmaturemyeloidcells,aconditiontermedmyelokathexis.
      SIMILARITY:BelongstotheG-proteincoupledreceptor1family.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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