當(dāng)前位置 ： Millipore >>> Millipore/AB2253 | Anti-Doublecortin Antibody/AB2253/50 µL
Millipore/AB2253 | Anti-Doublecortin Antibody/AB2253/50 µL
  • Millipore/AB2253 | Anti-Doublecortin Antibody/AB2253/50 µL

Millipore/AB2253 | Anti-Doublecortin Antibody/AB2253/50 µL

價格: ￥4932.00 市場價: 8220.00
貨號: AB2253
品牌: Millipore
規(guī)格
數(shù)量
庫存(0)
特別 提示
代購產(chǎn)品：無質(zhì)量問題不接受退換貨，下單前請仔細(xì)核對信息。
下單后請及時聯(lián)系客服核對商品價格，訂單生效后再付款。
資深產(chǎn)品顧問
咨詢顧問

全國免費服務(wù)熱線

4000-520-616

  • 自營商城 一站式服務(wù)
  • 廠家直采 剔除溢價
  • 品質(zhì)甄選 正品保證
  • 嚴(yán)控流程 只做188精品
  • 極速物流 如約送貨
  • 詳情
  • 使用說明
  • 常見問題
    • Description
      CatalogueNumberAB2253
      ReplacesAB5910
      DescriptionAnti-DoublecortinAntibody
      AlternateNames
      • doublecortex
      • lissencephaly,X-linked(doublecortin)
      BackgroundInformationDoublecortin(DCX)isamicrotubule-associatedproteinexpressedalmostexclusivelyinimmatureneurons.NeuronalprecursorsbegintoexpressDCXshortlyafterexitingthecellcycle,andcontinuetoexpressDCXfor2-3weeksasthecellsmatureintoneurons.DownregulationofDCXbeginsafter2weeks,andoccursatthesametimethatthesecellsbegintoexpress,aMarkerformatureneurons.DuetothenearlyexclusiveexpressionofDCXindevelopingneurons,thisproteinhasbeenusedincreasinglyasamarkerforneurogenesis.Indeed,thelevelsofDCXexpressionincreaseinresponsetoexercise,whichoccursinparallelwithincreasedBrdUlabelling,currentlya"goldstandard"inmeasuringneurogenesis.
      ProductInformation
      FormatSerum
      Control
      • RatBrainlysate.
      PresentationGST-DepletedSerawith0.05%NaN3.
      StorageandShippingInformation
      StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto1yearafterdateofreceipt.
      Applications
      ApplicationThisAnti-DoublecortinAntibodyisvalidatedforuseinWB,IH,ICforthedetectionofDoublecortin.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry
      • Immunocytochemistry
      ApplicationNotesImmunohistochemistry:
      1:1,000–1:15,000onfreefloatingbrainsections.Optimaldilutionsneedtobedeterminedbytheenduser.

      Immunocytochemistry:
      Testedonmouseprimaryneurons.Optimaldilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenRecombinantPeptide.
      EpitopeC-Terminus
      HostGuineaPig
      SpecificityCat.#AB2253recognizestheC-TerminusofDoublecortin.
      SpeciesReactivity
      • Rat
      • Mouse
      SpeciesReactivityNoteMouseandRat.Expectedtoreactwithhumanbasedonsequencehomology.Reactivitywithotherspecieshasnotbeendetermined.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryInthedevelopingcortex,corticalneuronsmustmigrateoverlongdistancestoreachthesiteoftheirfinaldifferentiation.TheproteinencodedbythisgeneisacytoplasmicproteinwhichappearstodirectneuronalmigrationbyregulatingtheorganizationandstABIlityofmicrotubules.Theencodedproteincontainstwodoublecortindomains,whichbindmicrotubules.Inaddition,theencodedproteininteractswithLIS1,theregulatorygammasubunitofplateletactivatingfactoracetylhydrolase,andthisinteractionisimportanttopropermicrotubulefunctioninthedevelopingcortex.MutationsinthisgeneareacauseofX-linkedlissencephaly.Multipletranscriptvariantsencodingatleastthreedifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq]
      GeneSymbol
      • DBCN
      • DC
      • Doublin
      • LISX
      • Lis-X
      • Lissencephalin-X
      • OTTHUMP00000062892
      • SCLH
      • XLIS
      • doublecortex
      • doublecortin
      • doublin
      • lissencephalin-X
      PurificationMethodGSTDepletion
      UniProtNumber
      UniProtSummaryFUNCTION:Seemstoberequiredforinitialstepsofneuronaldispersionandcortexlaminationduringcerebralcortexdevelopment.MayactbycompetingwiththeputativeneuronalproteinkinaseDCAMKL1inbindingtoatargetprotein.Mayinthatwayparticipateinasignalingpathwaythatiscrucialforneuronalinteractionbeforeandduringmigration,possIBLyaspartofacalciumion-dependentsignaltransductionpathway.MaybepartwithLIS-1ofanoverlapping,butdistinct,signalingpathwaysthatpromoteneuronalmigration.

      SUBUNITSTRUCTURE:Interactswithtubulin.

      SUBCELLULARLOCATION:Cytoplasm.

      TISSUESPECIFICITY:Highlyexpressedinneuronalcellsoffetalbrain(inthemajorityofcellsofthecorticalplate,intermediatezoneandventricularzone),butnotexpressedinotherfetaltissues.Intheadult,highlyexpressedinthebrainfrontallobe,butverylowexpressioninotherregionsofbrain,andnotdetectedinheart,placenta,lung,liver,skeletalmuscles,kidneyandpancreas.

      DISEASE:DefectsinDCXarethecauseoflissencephalyX-linkedtype1(LISX1)[MIM:300067];alsocalledX-LISorLIS.LISX1isaclassiclissencephalycharacterizedbymentalretardationandseizuresthataremoresevereinmalepatients.Affectedboysshowanabnormallythickcortexwithabsentorseverelyreducedgyri.Clinicalmanifestationsincludefeedingproblems,abnormalmusculartone,seizuresandseveretoprofoundpsychomotorretardation.Femalepatientsdisplayalessseverephenotypereferredtoas"doublecortex".Ref.1Ref.2Ref.9Ref.10Ref.18Ref.21

      DefectsinDCXarethecauseofsubcorticalbandheterotopiaX-linked(SBHX)[MIM:300067];alsoknownasdoublecortexorsubcorticallaminarheterotopia(SCLH).SBHXisamildbrainmalformationofthelissencephalyspectrum.Itischaracterizedbybilateralandsymmetricplatesorbandsofgraymatterfoundinthecentralwhitematterbetweenthecortexandcerebralventricles,cerebralconvolutionsusuallyappearingnormal.Ref.11Ref.12Ref.13Ref.14Ref.15Ref.16Ref.17Ref.19

      AchromosomalaberrationinvolvingDCXisfoundinlissencephaly.Translocationt(X;2)(q22.3;p25.1).

      SEQUENCESIMILARITY:Contains2doublecortindomains.

      MolecularWeightApprox.45kDa.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
    售后保障
    螞蟻淘生物188，秉承螞蟻淘一貫的嚴(yán)謹(jǐn)態(tài)度，由螞蟻淘公司專業(yè)人員負(fù)責(zé)品控、采購、物流、銷售、售后，保障正品優(yōu)質(zhì)。以“快速好省，為科研提供好產(chǎn)品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴(yán)格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產(chǎn)品帶給科研！? 力求給你最優(yōu)質(zhì)的商品。
  • Q：生物188產(chǎn)品正品保障嗎？
    A：生物188質(zhì)量把控人員具有十年的從業(yè)經(jīng)驗，在業(yè)界享有良好的口碑；自營商城，直接從廠家采購， 自己的團隊負(fù)責(zé)國際物流和清關(guān)，中間沒有第三方，所有流程嚴(yán)格把控，100%保證正品，假一罰十。

    Q：下單后可以修改訂單嗎？
    A：下單后的商品付款之前可以修改；訂單付款成功，需要聯(lián)系我們客服進行修改；客服電話：4000-520-616

    Q：可以開發(fā)票嗎？
    A：本網(wǎng)站所售商品都是正規(guī)清關(guān)，均開具16%正規(guī)發(fā)票，發(fā)票金額含配送費金額，另有說明的除外。

    Q：商品幾天可以發(fā)貨？
    A：生物188商品，全部現(xiàn)貨銷售，付款后即可發(fā)貨,一般一周內(nèi)送達！

    Q：如何聯(lián)系商家？
    A：有任何問題夠可以電話咨詢我們，全國24小時免費服務(wù)熱線：4000-520-616 或聯(lián)系我們的在線客服QQ：1570468124

    Q：收到的商品少了/發(fā)錯了怎么辦？
    A：同個訂單購買多個商品可能會分為一個以上包裹發(fā)出，可能不會同時送達，建議查看訂單詳情是否是 部分發(fā)貨狀態(tài)；如未收到，可聯(lián)系在線客服或者致電4000-520-616。

    Q：退換貨/維修需要多長時間？
    A：一般情況下，退貨處理周期為客戶收到產(chǎn)品一個月內(nèi)（以快遞公司顯示簽收時間為準(zhǔn)），包裝規(guī)格、 數(shù)量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內(nèi)申請退換貨；特殊商品以合同條款為準(zhǔn)。

何為188

極簡而嚴(yán)謹(jǐn)，我們僅銷售188款生物醫(yī)學(xué)科研用品，款款都是爆款；因為少所以聚焦，聚焦甄選每一款產(chǎn)品，聚焦服務(wù)每一位客戶!

關(guān)注我們 :

點擊QQ聯(lián)系我們
生物188微信

關(guān)注188微信公眾號

獲取最新優(yōu)惠活動通知

  • 品質(zhì)甄選，正品保證

  • 自營電商，廠家直采

  • 極簡主義，188精品