BackgroundInformation | Ephrinreceptorsandtheirligands,theephrins,mediatenumerousdevelopmentalprocesses,particularlyinthenervoussystem.Basedontheirstructuresandsequencerelationships,ephrinsaredividedintotheephrin-A(EFNA)class,whichareanchoredtothemembranebyaglycosylphosphatidylinositollinkage,andtheephrin-B(EFNB)class,whicharetransmembraneproteins.TheEphfamilyofreceptorsaredividedinto2groupsbasedonthesimilarityoftheirextracellulardomainsequencesandtheiraffinitiesforbindingephrin-Aandephrin-Bligands.Ephrinreceptorsmakeupthelargestsubgroupofthereceptortyrosinekinase(RTK)family.Theproteinencodedbythisgeneisareceptorforephrin-Bfamilymembers. |