Immunogen | SyntheticpeptideneartheN-terminushuman/rat/mouseHuC. |
Epitope | N-Terminus |
Host | Rabbit |
Specificity | HuC.ByWesternblottheantibodyreactswithabandat~39kDaonadultratbrainlysateandratspinalcordlysate.Anadditionalbandat~25kDamaybeseendependingonsampleandantibodyconcentrationused. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | AmemberoftheELAVLproteinfamily,ELAV-like3isaneural-specificRNA-bindingproteinwhichcontainsthreeRNP-typeRNArecognitionmotifs.TheobservationthatELAVL3isoneofseveralHuantigens(neuronal-specificRNA-bindingproteins)recognizedbytheanti-Huserumantibodypresentinserafrompatientswithparaneoplasticencephalomyelitisandsensoryneuronopathy(PEM/PSN)suggestsithasaroleinneurogenesis.Twoalternativelysplicedtranscriptvariantsencodingdistinctisoformshavebeenfoundforthisgene. |
GeneSymbol | - ELAVL3
- PLE21
- HUCL
- MGC20653
- HUC
- HuC
- DKFZp547J036
|
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q14576#Maybeinvolvedinneuronaldifferentiationandmaintenance. SIZE:367aminoacids;39547Da TISSUESPECIFICITY:Brainspecific. SIMILARITY:SwissProt:Q14576##BelongstotheRRMelavfamily.&Contains3RRM(RNArecognitionmotif)domains. |
MolecularWeight | 39.5kDa |