Immunogen | Denaturedtyrosinehydroxylasefromratpheochromocytoma(denaturedbysodiumdodecylsulfate). |
Host | Rabbit |
Specificity | Tyrosinehydroxylase.Bywesternblot,AB152selectivelabelsasinglebandatapproximately62kDa(reduced)correspondingtoTyrosineHydroxylase.Itisexpectedthattheantibodywillreactwithmostmammalianandmanynon-mammalianspecies.Ithasbeenreportedthatthisantibodydoesnotworkonparaffinembeddedhumantissue. |
SpeciesReactivity | - Human
- Rat
- Mouse
- Feline
- Ferret
- Squid
- Drosophila
- Mollusk
|
SpeciesReactivityNote | Rat,mouse,ferret,feline,Aplysia(marinemollusc).Itisexpectedthattheantibodywillreactwithmostmammalianandmanynon-mammalianspecies.Ithasbeenreportedthatthisantibodydoesnotworkonparaffinembeddedhumantissue. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. |
GeneSymbol | |
PurificationMethod | AffinityPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. |
MolecularWeight | 62kDa |