EntrezGeneSummary | Cofilinisawidelydistributedintracellularactin-modulatingproteinthatbindsanddepolymerizesfilamentousF-actinandinhibitsthepolymerizationofmonomericG-actininapH-dependentmanner.(Gillettetal.,1996[PubMed8800436]).Cofilin-2isamemberoftheACgroupofproteinsthatalsoincludescofilin-1(CFL1)anddestrin(DSTN;MIM609114),allofwhichregulateactin-filamentdynamics(Bamburgetal.,1999[PubMed10461190];MaciverandHussey,2002).TheCFL2geneencodesaskeletalmuscle-specificisoform(Vartiainenetal.,2002[PubMed11809832])localizedtothethinfilaments,whereitexertsitseffectonactin,inpartthroughinteractionswithtropomyosins(OnoandOno,2002[PubMed11901171]).[suppliedbyOMIM] |