Immunogen | 18aminoacidpeptidesequencewithintheextracellular,N-terminusofhumanTie-2 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizeshumanTunicainternalendothelialcellkinase(TIE-2),alsodescribedasAngiopoietin-1receptor,p140TEK,ortyrosineproteinkinasereceptor.Thepeptidesequenceusedasimmunogenis100%conservedinhuman,rat,mouse,and94%inbovine. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
GeneSymbol | - CD202B
- CD202b
- EC2.7.10.1
- OTTHUMP00000021167
- TIE-2
- TIE2
- VMCM
- VMCM1
- hTIE2
|
PurificationMethod | AffinityPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.Itmayconstitutetheearliestmammalianendothelialcelllineagemarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation. CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate. SUBUNITSTRUCTURE:InteractswithPTPRB. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney. PTM:Phosphorylated.PhosphorylationisinducedbyANGPT1andANGPT2.ANGPT1-inducedphosphorylationisimpairedduringhypoxia.DephosphorylatedbyPTPRB. INVOLVEMENTINDISEASE:DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily. Contains3EGF-likedomains. Contains3fibronectintype-IIIdomains. Contains2Ig-likeC2-type(immunoglobulin-like)domains. Contains1proteinkinasedomain. |
MolecularWeight | Approx.126kDa |