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Millipore/06-852 | Anti-Spinophilin/Neurabin-II Antibody/06-852/200 µg
  • Millipore/06-852 | Anti-Spinophilin/Neurabin-II Antibody/06-852/200 µg

Millipore/06-852 | Anti-Spinophilin/Neurabin-II Antibody/06-852/200 µg

價(jià)格: ￥4812.00 市場(chǎng)價(jià): 8020.00
貨號(hào): 06-852
品牌: Millipore
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    • Description
      CatalogueNumber06-852
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-Spinophilin/NeurABIn-IIAntibody
      AlternateNames
      • Proteinphosphatase1regulatorysubunit9B3neurabinII
      • proteinphosphatase1,regulatory(inhibitor)subunit9B
      • proteinphosphatase1,regulatorysubunit9B
      • proteinphosphatase1,regulatorysubunit9B
      • spinophilin
      BackgroundInformationSpinophilin/neurabinIIisanactin-associatedscaffoldingproteinenrichedinthedendriticspinesofneurons.
      ProductInformation
      FormatPurified
      Control
      • Braintissue
      PresentationPurifiedrabbitpolyclonalIgGinbuffercontaining70%storagebuffer(0.014Mphosphatebuffer,pH7.6,0.175MNaCl,0.07%sodiumazide)and30%glycerol.Storeat-20°C.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.

      HandlingRecommendations:
      Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:Variabilityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationAnti-Spinophilin/Neurabin-IIAntibodyisanantibodyagainstSpinophilin/Neurabin-IIforuseinIC,IP&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunoprecipitation:
      4μgofapreviouslotimmunoprecipitatedSpinophilin/Neurabin-IIfrom500μgofratbrainmicrosomalpreparation(Catalog#12-144).
      BIOLOGicalInformation
      ImmunogenGSTfusionproteincorrespondingtoresidues286-390ofratbrainspinophilin/neurabin-II.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificitySpecificforspinophilin,Mr120kDa.AlsorecognizesabandwhichissUSPectedtobeacleavageproductofspinophilin,Mr95kDa.
      IsotypeIgG
      SpeciesReactivity
      • Rat
      SpeciesReactivityNoteRat.Otherspeciesnotknown.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummarySpinophilinisaregulatorysubunitofproteinphosphatase-1catalyticsubunit(PP1;seeMIM176875)andishighlyenrichedindendriticspines,specializedprotrusionsfromdendriticshaftsthatreceivemostoftheexcitatoryinputinthecentralnervoussystem(Allenetal.,1997[PubMed9275233]).[suppliedbyOMIM]
      GeneSymbol
      • PPP1R9B
      • PPP1R6
      • SPINO
      • Spinophilin
      • PPP1R9
      • Neurabin-2
      • FLJ30345
      • spinophilin
      • Neurabin-II
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q96SB3#Seemstoactasascaffoldproteininmultiplesignalingpathways.Modulatesexcitatorysynaptictransmissionanddendriticspinemorphology.Bindstoactinfilaments(F-actin)andshowscross-linkingactivity.BindsalongthesidesoftheF-actin.MayplayanimportantroleinlinkingtheactinCytoskeletontotheplasmamembraneatthesynapticjunction.Believedtotargetproteinphosphatase1/PP1todendriticspines,whicharerichinF-actin,andregulatesitsspecificitytowardionchannelsandothersubstrates,suchasAMPA-typeandNMDA-typeglutamatereceptors.PlaysaroleinregulationofG-proteincoupledreceptorsignaling,includingdopamineD2receptorsandalpha-adrenergicreceptors.MayestablishasignalingcomplexfordopaminergicneurotransmissionthroughD2receptorsbylinkingreceptorsdownstreamsignalingmoleculesandtheactincytoskeleton.BindstoADRA1BandRGS2andmediatesregulationofADRA1Bsignaling.MayconfertoRacsignalingspecificitybybindingtoboth,RacGEFsandRaceffectorproteins.Probablyregulatesp70S6kinaseactivitybyformingacomplexwithTIAM1(Bysimilarity).


      SIZE:815aminoacids;89192Da

      SUBUNIT:PossIBLyexistsasanhomodimer,homotrimeroranhomotetramer.InteractswithF-actin,PPP1CA,neurabin-1,TGN38andD(2)dopaminereceptor.InteractswithRGS1,RGS2,RGS4,RGS19andADRA1B,ADRA2A,ADRA2B,ADRA2C,CDKN2A,PPP1R2,RASGFR1andTIAM1.

      SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Nucleus(Bysimilarity).Cellprojection,dendriticspine(Bysimilarity).Celljunction,synapse.Note=Enrichedatsynapseandcadherin-basedcell-celladhesionsites.Inneurons,bothcytosolicandmembrane-associated,andhighlyenrichedinthepost-synapticdensityapposedtoexitatorysynapses.ColocalizeswithPPP1R2atactin-richadherensjunctionsinepithelialcellsandindendriticspines(Bysimilarity).


      PTM:StimulationofD1(butnotD2)dopaminereceptorsinducesSer-94phosphorylation.DephosphorylationofSer-94ismediatedmainlybyPP1andtoalesserextentbyPP2A.PhosphorylationofspinophilindisruptsitsassociationwithF-actin,butdoesnotaffectitsbindingtoPP1(Bysimilarity).


      SIMILARITY:SwissProt:Q96SB3##Contains1PDZ(DHR)domain.
      MolecularWeight120kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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