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Millipore/06-340 | Anti-Myc Antibody/06-340/100 µg
  • Millipore/06-340 | Anti-Myc Antibody/06-340/100 µg

Millipore/06-340 | Anti-Myc Antibody/06-340/100 µg

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貨號: 06-340
品牌: Millipore
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    • Description
      CatalogueNumber06-340
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-MycAntibody
      AlternateNames
      • Transcriptionfactorp64
      • avianmyelocytomatosisviraloncogenehomolog
      • mycproto-oncogeneprotein
      • v-mycavianmyelocytomatosisviraloncogenehomolog
      • v-mycmyelocytomatosisviraloncogenehomolog(avian)
      BackgroundInformationc-Myc-,N-Myc-andL-Myc-encodedproteinsfunctionincellproliferation,differentiationandneoplasticdisease.Mycproteinsarenuclearproteinswithrelativelyshorthalflives.Amplificationofthec-Mycgenehasbeenfoundinseveraltypesofhumantumorsincludinglung,breastandcoloncarcinomas,whiletheN-Mycgenehasbeenfoundamplifiedinneuroblastomas.TheL-Mycgenehasbeenreportedtobeamplifiedandexpressedathighlevelinhumansmallcelllungcarcinomas.Thec-Mycproteinisatranscriptionfactor,whichisencodedbythec-Mycgeneonhumanchromosome8q24.c-Myciscommonlyactivatedinavarietyoftumorcellsandplaysanimportantroleincellularproliferation,differentiation,apoptosisandcellcycleprogression.
      ProductInformation
      FormatPurified
      Control
      • EGF-stimulatedA431cells,normalhumancolon,HeLawholecelllysateorJurkatwholecelllysate.
        IncludedPositiveAntigenControl:Catalog#12-302,EGF-stimulatedA431celllysate.Add2.5μLof2-mercaptoethanolper100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
      PresentationPurifiedrabbitpolyclonalIgGinbuffercontainingPBS,0.05%sodiumazidewith2mg/mLBSA.Frozensolution.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.

      HandlingRecommendations:
      Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationUseAnti-MycAntibody(rabbitpolyclonalantibody)validatedinChIP,ICC,IP,WBtodetectMycalsoknownasTranscriptionfactorp64,avianmyelocytomatosisviraloncogenehomolog,mycproto-oncogeneprotein.
      KeyApplications
      • Immunocytochemistry
      • Immunoprecipitation
      • WesternBlotting
      • ChromatinImmunoprecipitation(ChIP)
      ApplicationNotesImmunoprecipitation:
      4μgofapreviousantibodyimmuno-precipitatedMycasshownbyanindependentlaboratory.

      Immunocytochemistry:
      Thisantibodyhasbeenusedforimmunocytochemistrybyanindependentlaboratory.(Ohtsuka,T.,1998)
      BIOLOGicalInformation
      ImmunogenBacteriallyexpressedfusion-proteincorrespondingtothefull-lengthhumanMyc.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesMycisoformsMr50-67kDa.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Avian
      • Xenopus
      SpeciesReactivityNoteStrongestreactivityobservedwithhumanandmouseMyc.Willalsocross-reactwithavianandXenopus.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamultifunctional,nuclearphosphoproteinthatplaysaroleincellcycleprogression,apoptosisandcellulartransformation.Itfunctionsasatranscriptionfactorthatregulatestranscriptionofspecifictargetgenes.Mutations,overexpression,rearrangementandtranslocationofthisgenehavebeenassociatedwithavarietyofhematopoietictumors,leukemiasandlymphomas,includingBurkittlymphoma.Thereisevidencetoshowthatalternativetranslationinitiationsfromanupstream,in-framenon-AUG(CUG)andadownstreamAUGstartsiteresultintheproductionoftwoisoformswithdistinctN-termini.Thesynthesisofnon-AUGinitiatedproteinissuppressedinBurkitt"slymphomas,suggestingitsimportanceinthenormalfunctionofthisgene.
      GeneSymbol
      • MYC
      • C-MYC
      • c-Myc
      PurificationMethodImmunoaffinityChromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P01106#Participatesintheregulationofgenetranscription.BindsDNAbothinanon-specificmannerandalsospecificallytorecognizesthecoresequence5"-CAC[GA]TG-3".Seemstoactivatethetranscriptionofgrowth-relatedgenes.
      SIZE:439aminoacids;48804Da
      SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasaheterodimerwithMAX.InteractswithTAF1CandSPAG9.InteractswithPARP10.InteractswithJARID1AandJARID1B.
      SUBCELLULARLOCATION:Nucleus.
      PTM:PhosphorylatedbyPRKDC.
      DISEASE:SwissProt:P01106#OverexpressionofMYCisimplicatedintheetiologyofavarietyofhematopoietictumors.&AchromosomalaberrationinvolvingMYCmaybeacauseofaformofB-cellchroniclymphocyticleukemia.Translocationt(8;12)(q24;q22)withBTG1.
      SIMILARITY:SwissProt:P01106##Contains1basichelix-loop-helix(bHLH)domain....
      MolecularWeight67kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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