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Millipore/05-858R | Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal/05-858R/100 µL
  • Millipore/05-858R | Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal/05-858R/100 µL

Millipore/05-858R | Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal/05-858R/100 µL

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貨號(hào): 05-858R
品牌: Millipore
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    • Description
      CatalogueNumber05-858R
      DescriptionAnti-HistoneH4Antibody,pan,clone62-10C-2,rabbitmonoclonal
      AlternateNames
      • H4
      • HistoneH4
      • H4histonefamily,memberA
      • histone1,H4a
      • histonecluster1,H4a
      BackgroundInformationHistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.
      ProductInformation
      FormatPurified
      Control
      • HeLaacidextract
      PresentationPurifiedRabbitMonoclonalIgGSupernatantinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl),containing40%glycerolwith0.05%sodiumazide
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      Applications
      ApplicationUseAnti-HistoneH4Antibody,pan,clone62-10C-2(RabbitMonoclonalAntibody)validatedinWBtodetectHistoneH4alsoknownasHistoneH4.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenKLH-conjugated,syntheticpeptidecorrespondingtoaminoacids17-28ofHistoneH4.
      EpitopeEpitopemappedtoresidues25-28.
      Clone62-10C-2
      HostRabbit
      SpecificityThisantibodyrecognizeshistoneH4.
      IsotypeIgG
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteDemonstratedtoreactwithonhuman.Broadspeciescross-reactivityexpectedbasedon100%sequencehomologytomultiplespecies.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.[providedbyRefSeq]
      GeneSymbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Swiss-ProtP62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.
      PTM:AcetylationatLys-6,Lys-9,Lys-13andLys-17occursincodingregionsofthegenomebutnotinheterochromatin.
      CitrullinationatArg-4byPADI4impairsmethylation.
      MonomethylationatArg-4byPRMT1favorsacetylationatLys-9andLys-13.DemethylationisperformedbyJMJD6.
      Monomethylated,dimethylatedortrimethylatedatLys-21.MonomethylationisperformedbySET8.TrimethylationisperformedbySUV420H1andSUV420H2andinducesgenesilencing.
      UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirradiation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.
      Sumoylated,whichisassociatedwithtranscriptionalrepression.
      SEQUENCESIMILARITIES:BelongstothehistoneH4family.
      MolecularWeight10kDaObserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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