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Millipore/05-443 | Anti-VEGF Antibody, clone JH/05-443/100 µg
  • Millipore/05-443 | Anti-VEGF Antibody, clone JH/05-443/100 µg

Millipore/05-443 | Anti-VEGF Antibody, clone JH/05-443/100 µg

價格: ￥3696.00 市場價: 6160.00
貨號: 05-443
品牌: Millipore
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    • Description
      CatalogueNumber05-443
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-VEGFAntibody,cloneJH
      AlternateNames
      • VascularpermeABIlityfactor
      • vascularendothelialgrowthfactor
      • vascularendothelialgrowthfactorA
      • vascularendothelialgrowthfactorisoformVEGF165
      BackgroundInformationTheFltgenefamilyofreceptortyrosinekinasesincludesFlt-1,KDR/Flk-1,Flt-3,andFlt-4.TheyencodereceptorsforVEGF,characterizedbysevenIg-loopswithintheirextracellulardomainandasplitkinasedomainwithinthecytoplasmicdomain.VEGFisanimportantangiogenicfactorofmanysolidtumorsandisalsoinvolvedinthedifferentiationofendothelialcells.Flt-1(Fms-liketyrosinekinase,VEGF-R1)isexpressedonendothelialcellsandonthecommonprecursorsofendothelialandhematopoieticstemcells.KDR(Flk-1,VEGF-R2)istheprincipalreceptorinvolvedinVEGFsignaling.KDRisexpressedonendothelialcellsandstimulatesangiogenesis,butisalsoexpressedonbonemarrowcells,andisthoughttoplayaroleindrivingtheproliferationofmostorallleukemiccells.Flt3isaclassIIIreceptortyrosinekinasethatiscloselyrelatedtoc-Kitandc-Fms.Itisexpressedinprimitivehematopoieticcellsanditsligandexertsproliferativeeffectsonthesecellsinco-operationwithothercytokines.Flt3isalsoexpressedtheplacenta,testis,spleen,thymus,bonemarrow,brainandincerebellarPurkinjecells.TheVEGFreceptorsstimulatetheRas-MAPkinasepathway,suggestingthatitsignalsasaconventionalreceptortyrosinekinase.
      ProductInformation
      FormatPurified
      Control
      • Expressedinmosttissue,includingPancreas,Kidney,Adenocarcinoma.
      PresentationPurifiedmousemonoclonalIgG1kinbuffercontaining10mMPBS,pH7.4.
      StorageandShippingInformation
      StorageConditionsStablefor1yearatfromdateofreceipt.
      Applications
      ApplicationThisAnti-VEGFAntibody,cloneJHisvalidatedforuseinIH(P)forthedetectionofVEGF.
      KeyApplications
      • Immunohistochemistry(Paraffin)
      ApplicationsNotRecommended
      • WesternBlotting
      ApplicationNotesImmunohistochemistry:ThislotofantibodydetectedVEGFinformalinfixed,paraffinembedded,human.tissues,usinga1:50dilutionincubatedovernightat4°C.

      Immunoprecipitation:2μgofthisantibodyhasbeenreportedtoimmunoprecipitateVEGFfrom1mgofproteinlysate.
      BIOLOGicalInformation
      ImmunogenRecombinanthumanVEGF121.CloneJH121
      ClonecloneJH
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityRecognizes34-54kDaisoformsofVascularEndothelialGrowthFactor/VascularPermeabilityFactor(VEGF/VPF).
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Rabbit
      SpeciesReactivityNoteHuman,rabbit,mouse,andrat.Otherspeciesnottested.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneisamemberofthePDGF/VEGFgrowthfactorfamilyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.ElevatedlevelsofthisproteinislinkedtoPOEMSsyndrome,alsoknownasCrow-Fukasesyndrome.Mutationsinthisgenehavebeenassociatedwithproliferativeandnonproliferativediabeticretinopathy.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Thereisalsoevidencefortheuseofnon-AUG(CUG)translationinitiationsitesupstreamof,andin-framewiththefirstAUG,leADIngtoadditionalisoforms.
      GeneSymbol
      • VEGFA
      • VEGF-A
      • VEGF
      • VPF
      • MGC70609
      PurificationMethodProteinGChromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P15692#Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145.
      SIZE:232aminoacids;27042Da
      SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity).
      SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin.
      TISSUESPECIFICITY:TheVEGF189,VEGF-165andVEGF-121isoformsarewidelyexpressed,whereastheVEGF206andVEGF-145areuncommon.
      SIMILARITY:SwissProt:P15692##BelongstothePDGF/VEGFgrowthfactorfamily.
      MolecularWeight34-54kDaisoforms
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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