當(dāng)前位置 : Millipore >>> Millipore/05-412 | Anti-GSK3 Antibody, clone 4G-1E/05-412/100 µg
Millipore/05-412 | Anti-GSK3 Antibody, clone 4G-1E/05-412/100 µg
  • Millipore/05-412 | Anti-GSK3 Antibody, clone 4G-1E/05-412/100 µg

Millipore/05-412 | Anti-GSK3 Antibody, clone 4G-1E/05-412/100 µg

價(jià)格: ¥4308.00 市場價(jià): 7180.00

貨號(hào): 05-412
品牌: Millipore
規(guī)格
數(shù)量
庫存(0)
特別 提示
代購產(chǎn)品:無質(zhì)量問題不接受退換貨,下單前請仔細(xì)核對信息。
下單后請及時(shí)聯(lián)系客服核對商品價(jià)格,訂單生效后再付款。
資深產(chǎn)品顧問
咨詢顧問

全國免費(fèi)服務(wù)熱線

4000-520-616


  • 自營商城 一站式服務(wù)
  • 廠家直采 剔除溢價(jià)
  • 品質(zhì)甄選 正品保證
  • 嚴(yán)控流程 只做188精品
  • 極速物流 如約送貨
  • 詳情
  • 使用說明
  • 常見問題
    • Description
      CatalogueNumber05-412
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-GSK3Antibody,clone4G-1E
      AlternateNames
      • GSK-3alpha
      • glycogensynthasekinase3alpha
      BackgroundInformationGlycogensynthasekinase-3(GSK-3),amultifunctionalserine/threoninekinase,isakeyregulatorofnumeroussignalingpathways.TwoisoformsofGSK-3arereportedinmammals:a51kDaGSK-3aanda47kDaGSK-3b.Thesetwoisoformsexhibitabout98%homologyintheirkinasedomains,butshareonlyabout36%identityinthelast76C-terminalaminoacidresidues.GSK-3acontainsaglycine-richextensionatitsN-terminus.Aminor(~15%oftotal)splicevariantofGSK-3b,GSK-3b2,hasalsobeenidentified,whichcontainsa13-residueinsertwithinthekinasedomain.Itexhibitsreducedkinaseactivitytowardstauproteincomparedwith‘unspliced’GSK-3b.GSK-3b2islocalizedprimarilytoneuronalcellbodies,unlikeunsplicedGSK-3bthatisalsofoundinneuronalprocesses.GSK-3bplaysakeyinhibitoryroleintheWntsignalingpathway.Wntgenesencodealargefamilyofsecreted,cysteine-richproteinsthatareimportantindevelopmentandinmaintenanceofadulttissues.AbnormalitiesinWntsignalingarereportedtopromotebothhumandgenerativediseasesandcancer.
      ProductInformation
      FormatPurified
      Control
      • Jurkatecelllysate,293Tcellextract,rabbitspleenfibroblasts

        IncludedPositiveAntigenControl:
        Catalog#12-303,Jurkatlysate.Add2.5μLof2-mercaptoethanolper100μLoflysateandboilfor5minutestoreducethepreparation.Use20μgperlaneforminigels.
      PresentationProteinGpurifiedmouseIgG1instoragebuffercontaining0.02Mphosphatebuffer,pH7.6,0.25MNaCl,and0.1%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-GSK3Antibody,clone4G-1EdetectslevelofGSK3&hasbeenpublished&validatedforuseinIC&WB.
      KeyApplications
      • Immunocytochemistry
      • WesternBlotting
      ApplicationsNotRecommended
      • Immunoprecipitation
      ApplicationNotesImmunoprecipitation:
      Notrecommended.

      Immunocytochemistry:
      10μg/mLofapreviouslotshowedpositiveimmunostainingforGSK3inL6cellsfixedwithacetone.
      BIOLOGicalInformation
      Immunogen18residuesyntheticpeptide(C-KQLLHGEPNVSYICSRY)correspondingtoaminoacids203-219derivedfromaregionofthecatalyticdomain(betweensuBDomainVIIandVIII)oftheDrosophilaGSK3/shaggyenzyme,coupledtoovalbumin.Clone4G-1E.
      Clone4G-1E
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityGSK3,αandβisoforms
      IsotypeIgG1
      SpeciesReactivity
      • Vertebrates
      • Mouse
      • Rat
      • Human
      • Dictyostelium
      • Yeast(S.pombe)
      SpeciesReactivityNoteMouse,rat,S.pombe,Dictyosteliumandhuman.Becauseoftheextremelyhighconservationofthisimmunogenamongtheknownenzymesofmanydifferentspecies,thisantibodyispredictedtocross-reactwithnearlyallspecieshomologues.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryGlycogensynthasekinase3-alpha(GSK3A;EC{2.7.1.37})isamultifunctionalproteinserinekinase,homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthase(seeGYS1,{138570})andtranscriptionfactors(e.g.,JUN,{165160}).ItalsoplaysaroleintheWNT({164820})andPI3K(seePIK3CG,{601232})signalingpathways(seereviewby{1:Alietal.(2001)}).[suppliedbyOMIM]
      GeneSymbol
      • GSK3A
      • DKFZp686D0638
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P49840#Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN(Bysimilarity).
      SIZE:483aminoacids;50981Da
      SUBUNIT:Monomer(Bysimilarity).
      SIMILARITY:SwissProt:P49840##Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.&Contains1protein
      MolecularWeight51kDa(α)or46kDa(β)
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
    售后保障
    螞蟻淘生物188,秉承螞蟻淘一貫的嚴(yán)謹(jǐn)態(tài)度,由螞蟻淘公司專業(yè)人員負(fù)責(zé)品控、采購、物流、銷售、售后,保障正品優(yōu)質(zhì)。以“快速好省,為科研提供好產(chǎn)品、好價(jià)格”為理念,直接鏈接原廠家,從全國各地原制造商嚴(yán)格挑選188款科研精品,剔除品牌溢價(jià),188生物新電商,把好的產(chǎn)品帶給科研!? 力求給你最優(yōu)質(zhì)的商品。
  • Q:生物188產(chǎn)品正品保障嗎?
    A:生物188質(zhì)量把控人員具有十年的從業(yè)經(jīng)驗(yàn),在業(yè)界享有良好的口碑;自營商城,直接從廠家采購, 自己的團(tuán)隊(duì)負(fù)責(zé)國際物流和清關(guān),中間沒有第三方,所有流程嚴(yán)格把控,100%保證正品,假一罰十。

    Q:下單后可以修改訂單嗎?
    A:下單后的商品付款之前可以修改;訂單付款成功,需要聯(lián)系我們客服進(jìn)行修改;客服電話:4000-520-616

    Q:可以開發(fā)票嗎?
    A:本網(wǎng)站所售商品都是正規(guī)清關(guān),均開具16%正規(guī)發(fā)票,發(fā)票金額含配送費(fèi)金額,另有說明的除外。

    Q:商品幾天可以發(fā)貨?
    A:生物188商品,全部現(xiàn)貨銷售,付款后即可發(fā)貨,一般一周內(nèi)送達(dá)!

    Q:如何聯(lián)系商家?
    A:有任何問題夠可以電話咨詢我們,全國24小時(shí)免費(fèi)服務(wù)熱線:4000-520-616 或聯(lián)系我們的在線客服QQ:1570468124

    Q:收到的商品少了/發(fā)錯(cuò)了怎么辦?
    A:同個(gè)訂單購買多個(gè)商品可能會(huì)分為一個(gè)以上包裹發(fā)出,可能不會(huì)同時(shí)送達(dá),建議查看訂單詳情是否是 部分發(fā)貨狀態(tài);如未收到,可聯(lián)系在線客服或者致電4000-520-616。

    Q:退換貨/維修需要多長時(shí)間?
    A:一般情況下,退貨處理周期為客戶收到產(chǎn)品一個(gè)月內(nèi)(以快遞公司顯示簽收時(shí)間為準(zhǔn)),包裝規(guī)格、 數(shù)量、品種不符,外觀毀損、短缺或缺陷,請?jiān)谑盏截?4小時(shí)內(nèi)申請退換貨;特殊商品以合同條款為準(zhǔn)。

何為188

極簡而嚴(yán)謹(jǐn),我們僅銷售188款生物醫(yī)學(xué)科研用品,款款都是爆款;因?yàn)樯偎跃劢梗劢拐邕x每一款產(chǎn)品,聚焦服務(wù)每一位客戶!

關(guān)注我們 :

點(diǎn)擊QQ聯(lián)系我們
生物188微信

關(guān)注188微信公眾號(hào)

獲取最新優(yōu)惠活動(dòng)通知
  • 品質(zhì)甄選,正品保證

  • 自營電商,廠家直采

  • 極簡主義,188精品