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Millipore/05-1355 | Anti-acetyl Histone H4 (Lys5/8/12/16) Antibody, clone 3HH4-4C10/05-1355/100 µL
  • Millipore/05-1355 | Anti-acetyl Histone H4 (Lys5/8/12/16) Antibody, clone 3HH4-4C10/05-1355/100 µL

Millipore/05-1355 | Anti-acetyl Histone H4 (Lys5/8/12/16) Antibody, clone 3HH4-4C10/05-1355/100 µL

價(jià)格: ￥4680.00 市場價(jià): 7800.00
貨號(hào): 05-1355
品牌: Millipore
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    • Description
      CatalogueNumber05-1355
      DescriptionAnti-acetylHistoneH4(Lys5/8/12/16)Antibody,clone3HH4-4C10
      AlternateNames
      • H4KAc
      • HistoneH4(acetyl)
      • H4histonefamily,memberN
      • H4histone,family2
      • histone2,H4
      • histone2,H4a
      • histoneIV,family2
      • histonecluster2,H4a
      BackgroundInformationHistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.AcetylationofhistoneH4occursatseveraldifferentlysinepositionsinthehistonetailandisperformedbyafamilyofenzymesknownasHistoneAcetylTransferases(HATs).PosttranslationalacetylationoftheconservedcorehistoneN-terminaltaildomainsistypicallyassociatedwithgeneactivation.
      ProductInformation
      FormatAscites
      Control
      • HeLaacidextractlysate
      PresentationUnpurifiedmousemonoclonalIgG1κpreservative-freeascites.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationUseAnti-acetylHistoneH4(Lys5/8/12/16)Antibody,clone3HH4-4C10(mousemonoclonalantibody)validatedinWB,ICCtodetectacetylHistoneH4(Lys5/8/12/16)alsoknownasH4KAc,HistoneH4(acetyl).
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      ApplicationNotesImmunocytochemistryAnalysis:
      1:500dilutionfromarepresentativelotdetectedHistoneH4inA431andHeLacells.
      BIOLOGicalInformation
      ImmunogenLinearpeptidecorrespondingtohumanHistoneH4acetylatedatLys5/8/12/16.
      EpitopeLys5/8/12/16
      Clone3HH4-4C10
      HostMouse
      SpecificityThisantibodyrecognizesHistoneH4.
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithhuman.Predictedtoreactwithmouseandratbasedon100%sequencehomology.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.
      GeneSymbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.

      SIZE:103aminoacids;11367Da

      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.

      SUBCELLULARLOCATION:Nucleus.

      PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.

      SIMILARITY:BelongstothehistoneH4family.
      MolecularWeight~13kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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