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Millipore/05-1352 | Anti-Histone H2B Antibody, clone 5HH2-2A8/05-1352/100 µL
  • Millipore/05-1352 | Anti-Histone H2B Antibody, clone 5HH2-2A8/05-1352/100 µL

Millipore/05-1352 | Anti-Histone H2B Antibody, clone 5HH2-2A8/05-1352/100 µL

價(jià)格: ￥4680.00 市場(chǎng)價(jià): 7800.00
貨號(hào): 05-1352
品牌: Millipore
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    • Description
      CatalogueNumber05-1352
      ReplacesMABE15
      DescriptionAnti-HistoneH2BAntibody,clone5HH2-2A8
      AlternateNames
      • H2B
      • HistoneH2B
      • histone2,H2be
      • histonecluster2,H2be
      • H2Bhistonefamily,memberQ
      BackgroundInformationHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofchromatinineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichDNAiswrappedinrepeatingunits,callednucleosomes.HistoneH2Bisoneofthemainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH2Bisinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.
      ProductInformation
      FormatAscites
      Control
      • HepG2celllysate,L6celllysate,MouseBrainLysate
      PresentationMousemonoclonalIgG1κasciteswith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-HistoneH2BAntibody,clone5HH2-2A8isaMouseMonoclonalAntibodyfordetectionofHistoneH2BalsoknownasHistoneH2B,histone2H2be&hasbeenvalidatedinWB,ICC.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      ApplicationNotesImmunocytochemistry:
      A1:500dilutionofarepresentativelotofthisantibodydetectedHistoneH2BinA431,HeLaandNIH/3T3cells.
      BIOLOGicalInformation
      ImmunogenOvalbumin-conjugatedsyntheticlinearpeptidecorrespondingtotheC-terminusofHistoneH2B.
      EpitopeC-terminus
      Cloneclone5HH2-2A8
      HostMouse
      SpecificityAntibodyrecognizesHistoneH2BneartheC-terminus.
      IsotypeIgG1κ
      SpeciesReactivity
      • Mouse
      • Human
      • Rat
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthesmallhistonegeneclusteronchromosome6p22-p21.3.[providedbyRefSeq]
      GeneSymbol
      • H2B
      • GL105
      • H2B-GL105
      • H2B.1
      • H2B.q
      • H2B/q
      • H2BFQ
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q8N257#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.

      SIZE:126aminoacids;13908Da

      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.

      SUBCELLULARLOCATION:Nucleus.

      PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.&PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination.

      SIMILARITY:SwissProt:Q8N257##BelongstothehistoneH2Bfamily.
      MolecularWeight~15kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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