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Millipore/05-101 | Anti-EGFR Antibody, neutralizing, clone LA1/05-101/250 µg
  • Millipore/05-101 | Anti-EGFR Antibody, neutralizing, clone LA1/05-101/250 µg

Millipore/05-101 | Anti-EGFR Antibody, neutralizing, clone LA1/05-101/250 µg

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貨號: 05-101
品牌: Millipore
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    • Description
      CatalogueNumber05-101
      Replaces04-337;04-338
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-EGFRAntibody,neutralizing,cloneLA1
      OverviewReactswithexternaldomainofEGFreceptoronallhumancells.CompeteswithEGFandTGF-aforbindingonhumancells.
      BackgroundInformationTheepidermalgrowthfactorreceptor(EGFR;ErbB-1;HER1inhumans)isthecell-surfacereceptorformembersoftheepidermalgrowthfactorfamily(EGF-family)ofextracellularproteinligands.TheepidermalgrowthfactorreceptorisamemberoftheErbBfamilyofreceptors,asubfamilyoffourcloselyrelatedreceptortyrosinekinases:EGFR(ErbB-1),HER2/c-neu(ErbB-2),Her3(ErbB-3)andHer4(ErbB-4).MutationsaffectingEGFRexpressionoractivitycouldresultincancer.EGFR(epidermalgrowthfactorreceptor)existsonthecellsurfaceandisactivatedbybindingofitsspecificligands,includingepidermalgrowthfactorandtransforminggrowthfactorα(TGFα).Uponactivationbyitsgrowthfactorligands,EGFRundergoesatransitionfromaninactivemonomericformtoanactivehomodimer.Inadditiontoforminghomodimersafterligandbinding,EGFRmaypairwithanothermemberoftheErbBreceptorfamily,suchasErbB2/Her2/neu,tocreateanactivatedheterodimer.ThereisalsoevidencetosuggestthatclustersofactivatedEGFRsform,althoughitremainsunclearwhetherthisclusteringisimportantforactivationitselforoccurssubsequenttoactivationofindividualdimers.
      EGFRdimerizationstimulatesitsintrinsicintracellularprotein-tyrosinekinaseactivity.Asaresult,autophosphorylationoffivetyrosine(Y)residuesintheC-terminaldomainofEGFRoccurs.TheseareY992,Y1045,Y1068,Y1148andY1173.Thisautophosphorylationelicitsdownstreamactivationandsignalingbyseveralotherproteinsthatassociatewiththephosphorylatedtyrosinesthroughtheirownphosphotyrosine-bindingSH2domains.Thesedownstreamsignalingproteinsinitiateseveralsignaltransductioncascades,principallytheMAPK,AktandJNKpathways,leADIngtoDNAsynthesisandcellproliferation.Suchproteinsmodulatephenotypessuchascellmigration,adhesion,andproliferation.ThekinasedomainofEGFRcanalsocross-phosphorylatetyrosineresiduesofotherreceptorsitisaggregatedwith,andcanitselfbeactivatedinthatmanner.
      ProductInformation
      FormatPurified
      Control
      • PositiveControlIncluded:Non-StimA431CellLysate(12-301)
      PresentationLyophilizedproteinGPurifiedmouseimmunoglobulin.Lyophilizedfrom0.1MTris-glycine,pH7.4,0.15MNaClcontainingnopreservatives.
      StorageandShippingInformation
      StorageConditionsLyophilized:2yearsat-20°C;Rehydrated:1monthat4°Cor6monthsat-20°C
      Applications
      ApplicationDetectEGFRusingthisAnti-EGFRAntibody,neutralizing,cloneLA1validatedforuseinIC,IP,NEUT&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunoprecipitation
      • Neutralizing
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenHumanA431membraneproteins.
      CloneLA1
      HostMouse
      SpecificityRecognizesbothphosphorylatedandnon-phosphorylatedhumanEGFreceptors.
      IsotypeIgG1
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • EGFR
      • ERBB1
      • ERBB
      • mENA
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P00533#Isoform2/truncatedisoformmayactasanantagoNIST.
      SIZE:1210aminoacids;134277Da
      SUBUNIT:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1.
      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform2:Secreted.
      TISSUESPECIFICITY:Expressedinplacenta.Isoform2isalsoexpressedinovariancancers.
      PTM:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.&MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur.DISEASE:SwissProt:P00533#DefectsinEGFRareassociatedwithlungcancer[MIM:211980].
      SIMILARITY:SwissProt:P00533##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily.&Contains1proteinkinasedomain.
      MISCELLANEOUS:BindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation.
      MolecularWeight180kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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