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Millipore/04-218 | Anti-CREB Antibody, clone E306, rabbit monoclonal/04-218/100 µL
  • Millipore/04-218 | Anti-CREB Antibody, clone E306, rabbit monoclonal/04-218/100 µL

Millipore/04-218 | Anti-CREB Antibody, clone E306, rabbit monoclonal/04-218/100 µL

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貨號(hào): 04-218
品牌: Millipore
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    • Description
      CatalogueNumber04-218
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-CREBAntibody,cloneE306,rabbitmonoclonal
      AlternateNames
      • cAMPresponsiveelementbindingprotein
      • activetranscriptionfactorCREB
      • transactivatorprotein
      BackgroundInformationCREB,cyclicAMP(cAMP)responseelement-bindingprotein,isaubiquitouslyexpressedbasicleucinezippertranscriptionfactorthatfunctionsinglucosehomeostasisandstimulatestheexpressionofnumerousgenesinresponsetogrowthfactors,hormones,neurotransmitters,ionfluxes,stresssignals,andhasbeenimplicatedinmemorybecauseifitsapparentroleinsynapticplasticity.CREBfunctionseitherbyitselforwithrelatedfamilymembers,whichincludeCREB,CREM,andATF-1,byforminghomo-andheterodimersthroughtheirbasicleucinezipper(bZIP)domains.TheCREBsignalingpathwayisactivatedbyextracellularligandsthatbindtocellsurfacereceptorsandrelaytheirmessagethroughvariousintracellularsecondmessengersresultingultimatelyintheactivationofnuclearCREBthroughphosphorylationofthetransactivationdomainatserine1332,4.TheclassicalmodelofCREBactivationisthroughPKA(cAMP-dependentproteinkinase).Inthenon-activestate,PKAresidesinthecytoplasmasaninactiveheterotetramerofpairedregulatoryandcatalyticsubunits.StimulationofcAMPcausesthereleasesofthecatalyticsubunitsofPKAthatpassivelydiffuseintothenucleusandinitiatesgeneexpressionbyphosphorylatingCREBatitstransactivationdomainonserine1331,2,3,4.CREBmediatestheactivationofcAMP-responsivegenesbybindingasadimertoaconservedcAMP-responsiveelement(CRE),5’-TGACGTCA-3’,locatedwithinthepromoterregionoftargetgenes.Targetgeneactivationisterminatedbytheserine/threoninephosphatasesPP-1-mediateddephospho-rylationofCREB.
      ProductInformation
      FormatCultureSupernatant
      Control
      • A431wholecelllysate.
      Presentation100μLofrabbitmonoclonalIgGin60%storagebuffer(50mMTris-Glycine(pH7.4),0.15MNaCl,0.01%sodiumazideand0.05%BSA)and40%glycerol.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.Anti-CREBAntibody,cloneE306,rabbitdetectslevelofCREB&hasbeenpublished&validatedforuseinFC,IC,IF,IH(P),IP&WB.
      KeyApplications
      • FlowCytometry
      • Immunocytochemistry
      • Immunofluorescence
      • Immunohistochemistry(Paraffin)
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesFlowCytometry:1:40dilutionfromapreviouslotwasusedonflowcytometry.

      Immunohistochemistry:1:250-500dilutionfromapreviouslotwasusedonimmunohistochemistry.

      Immunoprecipitation:1:80dilutionfromapreviouslotwasusedonimmunoprecipitation.

      Immunocytochemistry:1:250-500dilutionfromapreviouslotwasusedonimmunocytochemistry.

      BIOLOGicalInformation
      ImmunogenKLHconjugatedtoCREBlinearpeptide.
      EpitopeInternal
      CloneE306
      HostRabbit
      SpecificityThisantibodyrecognizesCREB.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteProventoreactwithhuman,ratandmouse.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • MGC9284
      • CREB
      UniProtNumber
      UniProtSummaryFunction:ThisproteinbindsthecAMPresponseelement(CRE),asequencepresentinmanyviralandcellularpromoters.CREBstimulatestranscriptiononbindingtotheCRE.TransciptionactivationisenhancedbytheTORCcoactivatorswhichactindependentlyofSer-133phosphorylation.ImplicatedinsynchronizationofcircADIanrhythmicity.
      Subunitstructure:InteractswithPPRC1.BindsDNAasadimer.Thisdimerisstabilizedbymagnesiumions.Interacts,throughthebZIPdomain,withthecoactivatorsTORC1/CRTC1,TORC2/CRTC2andTORC3/CRTC3.WhenphosphorylatedonSer-133,bindsCREBBPBysimilarity.
      Subcellularlocation:Nucleus.
      Post-translationalmodification:Stimulatedbyphosphorylation.PhosphorylationofbothSer-133andSer-142intheSCNregulatestheactivityofCREBandparticipatesincircadianrhythmgeneration.PhosphorylationofSer-133allowsCREBBPbindingBysimilarity.PhosphorylateduponDNAdamage,probablybyATMorATR.
      Sequencesimilarities:BelongstothebZIPfamily.
      Contains1bZIPdomain.
      Contains1KID(kinase-inducIBLe)domain.
      MolecularWeight~43kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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