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Millipore/04-1557 | Anti-SIRT1 Antibody, clone 10E4/04-1557/200 µL
  • Millipore/04-1557 | Anti-SIRT1 Antibody, clone 10E4/04-1557/200 µL

Millipore/04-1557 | Anti-SIRT1 Antibody, clone 10E4/04-1557/200 µL

價(jià)格: ￥5052.00 市場(chǎng)價(jià): 8420.00
貨號(hào): 04-1557
品牌: Millipore
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    • Description
      CatalogueNumber04-1557
      DescriptionAnti-SIRT1Antibody,clone10E4
      AlternateNames
      • SIR2-likeprotein1
      • sir2-like1
      • sirtuin(silentmatingtypeinformationregulation2homolog)1(S.cerevisiae)
      • sirtuin(silentmatingtypeinformationregulation2,S.cerevisiae,homolog)1
      • sirtuin1
      • sirtuintype1
      BackgroundInformationSir2isshortforSilentmatingtypeInformationRegulation-2.Sir2(whosehomologinmammalsisknownasSIRT1,SIR2L1orSir2α)isthenamesakeofafamilyofcloselyrelatedenzymes,thesirtuins.Membersofthisfamilyhavebeenfoundinnearlyallorganismsstudied.Sirtuinsarehypothesizedtoplayakeyroleinanorganism"sresponsetostresses(suchasheatorstarvation)andtoberesponsIBLefortheLifespan-extendingeffectsofcalorierestriction.SirtuinsactbyremovingacetylgroupsfromproteinsinthepresenceofNAD+;theyarethusclassifiedas"NAD+-dependentdeacetylases".Inmammals,SIRT1(themammalianhomologofSir2)hasbeenshowntodeacetylateandtherebydeactivatethep53protein.
      ProductInformation
      FormatPurified
      Control
      • HeLacelllysate
      PresentationPurifiedmousemonoclonalIgGκinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationUseAnti-SIRT1Antibody,clone10E4(mousemonoclonalantibody)validatedinWB,IP,ICC,IHC,ChIPtodetectSIRT1alsoknownassirtuin(silentmatingtypeinformationregulation2homolog)1,sirtuin1.
      KeyApplications
      • WesternBlotting
      • Immunoprecipitation
      • Immunocytochemistry
      • Immunohistochemistry
      • ChromatinImmunoprecipitation(ChIP)
      ApplicationNotesImmunoprecipitation:Reportedbyindependentresearcherusingrepresentativelot.
      ChromatinImmunopreiciptiation:Reportedbyindependentresearcherusingrepresentativelot.
      Immunohistochemistry:Reportedbyindependentresearcherusingrepresentativelot.
      BIOLOGicalInformation
      ImmunogenHis-taggedrecombinantproteincorrespondingtohumanSIRT1.
      EpitopeUnknown
      Clone10-E-4
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityThisantibodyrecognizesSIRT1.
      SpeciesReactivity
      • Human
      • Mouse
      SpeciesReactivityNoteDemonstratedtoreactwithhuman.DoesnotreactinmouseinIHC.Mousesequenceis100%identicaltoimmunogen,soitispredictedtoworkinwesternblotting.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Alternativesplicingresultsinmultipletranscriptvariants.[providedbyRefSeq].
      GeneSymbol
      • SIRT1
      • SIR2L1
      • hSIR2
      • hSIRT1
      • SIR2alpha
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:NAD-dependentdeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Deacetylates"Lys-382"ofp53/TP53andimpairsitsABIlitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD(+)/NADH,whichisessentialinskeletalmusclecelldifferentiation.Despitesomeabilitytodeacetylatehistonesinvitro,suchactivityiseitherweakorinexistentinvivo.IncaseofHIV-1infection,interactswithanddeacetylatestheviralTatprotein.

      COFACTOR:Binds1zincionpersubunit(Bysimilarity).

      SIZE:747aminoacids;81681Da

      SUBUNIT:InteractswithTAF1B.FoundinacomplexwithPCAFandMYOD1(Bysimilarity).InteractswithMLLT7/FOXO4,HES1,HEY2,p53/TP53andPML.

      SUBCELLULARLOCATION:Nucleus.Note=RecruitedtothenuclearbodiesviaitsinteractionwithPML.TISSUESPECIFICITY:Widelyexpressed.

      SIMILARITY:Belongstothesirtuinfamily.&Contains1deacetylasesirtuin-typedomain.

      MISCELLANEOUS:Redwine,whichcontainsresveratrol,mayparticipateinactivationofsirtuinproteins,andmaythereforeparticipateinanextendedlifespanasithasbeenobservedinyeast.
      MolecularWeight~110kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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