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Millipore/04-079 | Anti-trimethyl-Histone H4 (Lys20), Antibody, rabbit monoclonal/04-079/100 µL
  • Millipore/04-079 | Anti-trimethyl-Histone H4 (Lys20), Antibody, rabbit monoclonal/04-079/100 µL

Millipore/04-079 | Anti-trimethyl-Histone H4 (Lys20), Antibody, rabbit monoclonal/04-079/100 µL

價格: ￥4680.00 市場價: 7800.00
貨號: 04-079
品牌: Millipore
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    • Description
      CatalogueNumber04-079
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-trimethyl-HistoneH4(Lys20),Antibody,rabbitmonoclonal
      AlternateNames
      • H4K20me3
      • HistoneH4(trimethylK20)
      BackgroundInformationHistonesarenuclearproteinsthatformoctamericstructureswhichbindDNAtoformunitsofchromatincallednucleosomes.Thefamilyofhistones—H2A,H2B,H3,andH4—arekeyplayersingeneregulation.Theyundergoanumberofpost-translationalmodifications(PTM)inresponsetovariousstimuli,includingphosphorylationonserineandthreonineresiduesandmethylationonlysineresidues.PTMsproduceconfiguralchangesinhistoneproteinsthatmayinducenucleosomeremodelingandexposeorhideDNAsequencesfromtranscriptionalcomplexes.HistoneH4lysine20(H4K20)mayundergomono-,di-,ortrimethylation,whichiscatalyzedbythemethyltransferasePR-Set7(Set8orKMT5a).MethylatedH4K20playsaroleinregulatingDNAdamageresponses,mitosis,DNAreplication,andgeneexpression.TrimethylationofH4K20contributestogenesilencing,andisamarkoftherepressiveheterochromatinstate.
      ProductInformation
      FormatCultureSupernatant
      Presentation100μLofrabbitmonoclonalIgGcellculturesupernatantin0.1%sodiumazide
      StorageandShippingInformation
      StorageConditions2yearsat-20°Cfromdateofshipment
      Applications
      ApplicationDetecttrimethyl-HistoneH4(Lys20)usingthisAnti-trimethyl-HistoneH4(Lys20)Antibody,rabbitdemontratedperformanceinWB,ChIP&DB.
      KeyApplications
      • WesternBlotting
      • DotBlot
      • ChromatinImmunoprecipitation(ChIP)
      ApplicationNotesChromatinImmunoprecipitation:
      SonicatedchromatinpreparedfromHeLacells(1X106cellequivalentsperIP)weresubjectedtochromatinimmunoprecipitationusing10μLofeitheranegativecontrolsupernatant,orAnti-Trimethyl-HistoneH4(Lys20)antibodyandtheMagnaChIP?AKit(Cat.#17-610).Successfulimmunoprecipitationoftrimethyl-histoneH4(Lys20)-associatedDNAfragmentswasverifiedbyqPCRusingChIPPrimersB-Globin.PleaserefertotheEZ-MagnaChIP?A(Cat.#17-408)orEZ-ChIP?(Cat.#17-371)protocolforexperimentaldetails.

      DotBlotAnalysis:AbsuranceHistoneH3AntibodySpecificityArray(Cat.No.16-667)andAbsuranceHistoneH2A,H2B,H4AntibodySpecificityArray(Cat.No.16-665),whichcontainhistonepeptideswithvariousmodificationswereprobedwithCat.No04-079,Anti-trimethylHistoneH4(Lys20)(1:500dilution).ProteinswerevisualizedusingaDonkeyanti-rabbitIgGconjugatedtoHRPandachemiluminescencedetectionsystem.
      BIOLOGicalInformation
      ImmunogenPeptidecorrespondingtohumanHistoneH4containingthesequence[HRmethKVL]onwhichlysine20istrimethylated.
      HostRabbit
      SpecificityRecognizesHistoneH4whentrimethylatedonLys20.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Vertebrates
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarenuclearproteinsthatformoctamericstructureswhichbindDNAtoformunitsofchromatincallednucleosomes.Thefamilyofhistones—H2A,H2B,H3,andH4—arekeyplayersingeneregulation.Theyundergoanumberofpost-translationalmodifications(PTM)inresponsetovariousstimuli,includingphosphorylationonserineandthreonineresiduesandmethylationonlysineresidues.PTMsproduceconfiguralchangesinhistoneproteinsthatmayinducenucleosomeremodelingandexposeorhideDNAsequencesfromtranscriptionalcomplexes.HistoneH4lysine20(H4K20)mayundergomono-,di-,ortrimethylation,whichiscatalyzedbythemethyltransferasePR-Set7(Set8orKMT5a).MethylatedH4K20playsaroleinregulatingDNAdamageresponses,mitosis,DNAreplication,andgeneexpression.TrimethylationofH4K20contributestogenesilencing,andisamarkoftherepressiveheterochromatinstate.
      GeneSymbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      Modifications
      • Methylation
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SIZE:103aminoacids;11367Da
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.
      PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.
      SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family.
      MolecularWeight11kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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